S
Stephanie Brown
Researcher at University of Cambridge
Publications - 48
Citations - 3909
Stephanie Brown is an academic researcher from University of Cambridge. The author has contributed to research in topics: Medicine & Induced pluripotent stem cell. The author has an hindex of 22, co-authored 33 publications receiving 3282 citations. Previous affiliations of Stephanie Brown include University of Otago & Wellcome Trust.
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Journal ArticleDOI
Activin/Nodal signalling maintains pluripotency by controlling Nanog expression
Ludovic Vallier,Sasha Mendjan,Stephanie Brown,Zhenzhi Chng,Adrian Kee Keong Teo,Lucy E. Smithers,Matthew Trotter,Matthew Trotter,Candy H.-H. Cho,Amelie Martinez,Peter J. Rugg-Gunn,Gabrielle Brons,Roger A. Pedersen +12 more
TL;DR: It is demonstrated that Activin/Nodal signalling controls expression of the key pluripotency factor Nanog in human ESCs and in mouse EpiSCs, which prevents neuroectoderm differentiation induced by FGF signalling and limits the transcriptional activity of the Smad2/3 cascade, blocking progression along the endoderm lineage.
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Glutaredoxin 2 Catalyzes the Reversible Oxidation and Glutathionylation of Mitochondrial Membrane Thiol Proteins: IMPLICATIONS FOR MITOCHONDRIAL REDOX REGULATION AND ANTIOXIDANT DEFENSE *
Samantha M. Beer,Ellen R. Taylor,Stephanie Brown,Christina C. Dahm,Nikola J. Costa,Michael J. Runswick,Michael P. Murphy +6 more
TL;DR: The findings indicate that Grx2 plays a central role in the response of mitochondria to both redox signals and oxidative stress by facilitating the interplay between the mitochondrial glutathione pool and protein thiols.
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Pluripotency factors regulate definitive endoderm specification through eomesodermin
Adrian Kee Keong Teo,Sebastian J. Arnold,Matthew Trotter,Stephanie Brown,Lay Teng Ang,Zhenzhi Chng,Elizabeth J. Robertson,N. Ray Dunn,Ludovic Vallier +8 more
TL;DR: Together, these results provide for the first time a comprehensive molecular model connecting the transition from pluripotency to endoderm specification during mammalian development.
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The SMAD2/3 interactome reveals that TGFβ controls m 6 A mRNA methylation in pluripotency
Alessandro Bertero,Stephanie Brown,Pedro Madrigal,Pedro Madrigal,Anna Osnato,Daniel Ortmann,Loukia Yiangou,Juned Kadiwala,Nina C. Hubner,Igor Ruiz de los Mozos,Christoph Yves Sadée,An-Sofie Lenaerts,Shota Nakanoh,Rodrigo A. Grandy,Edward J. Farnell,Jernej Ule,Hendrik G. Stunnenberg,Sasha Mendjan,Ludovic Vallier,Ludovic Vallier +19 more
TL;DR: This analysis reveals that SMAD2/3 is involved in multiple molecular processes in addition to its role in transcription, and reveals the mechanism by which extracellular signalling can induce rapid cellular responses through regulation of the epitranscriptome.
Journal ArticleDOI
Signaling pathways controlling pluripotency and early cell fate decisions of human induced pluripotent stem cells.
Ludovic Vallier,Thomas Touboul,Thomas Touboul,Stephanie Brown,Candy H.-H. Cho,Bilada Bilican,Morgan Alexander,Jessica Cedervall,Siddharthan Chandran,Lars Ährlund-Richter,Anne Weber,Roger A. Pedersen +11 more
TL;DR: It is shown that human iPSCs rely on activin/nodal signaling to control Nanog expression and thereby maintain pluripotency, thus revealing their mechanistic similarity to human ESCs and showing that these pluripotent cell types are functionally equivalent.