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Matthew Wook Chang

Researcher at National University of Singapore

Publications -  123
Citations -  6583

Matthew Wook Chang is an academic researcher from National University of Singapore. The author has contributed to research in topics: Synthetic biology & Metabolic engineering. The author has an hindex of 38, co-authored 110 publications receiving 5193 citations. Previous affiliations of Matthew Wook Chang include Defence Science and Technology Agency & Cornell University.

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A polycationic antimicrobial and biocompatible hydrogel with microbe membrane suctioning ability

TL;DR: An antimicrobial hydrogel based on dimethyldecylammonium chitosan (with high quaternization)-graft-poly(ethylene glycol) methacrylate (DMDC-Q-g-EM) and poly(ethylenes glycol), which has excellent antimicrobial efficacy against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Fusarium solani is reported.
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Sharper and faster "nano darts" kill more bacteria: a study of antibacterial activity of individually dispersed pristine single-walled carbon nanotube.

TL;DR: This study elucidated several factors controlling the antibacterial activity of pristine SWCNTs and it provided an insight in developing strategies that can maximize theSWCNT application potentials while minimizing the health and environment risks.
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Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen

TL;DR: The development of a synthetic genetic system that enables Escherichia coli to sense and kill a pathogenic Pseudomonas aeruginosa strain through the production and release of pyocin is described, suggesting that E. coli carrying this system may provide a novel synthetic biology‐driven antimicrobial strategy that could potentially be applied to fighting P. aerug inosa and other infectious pathogens.
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Engineered probiotic Escherichia coli can eliminate and prevent Pseudomonas aeruginosa gut infection in animal models.

TL;DR: A modified version of the synthetic genetic system, including a gene encoding an anti-biofilm enzyme, is generated and the engineered probiotic shows in vivo prophylactic and therapeutic activity against P. aeruginosa during gut infection in two animal models (Caenorhabditis elegans and mice).
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Hollow fiber membrane decorated with Ag/MWNTs: Toward effective water disinfection and biofouling control

TL;DR: An alternative and safer water disinfection system consisting of silver nanoparticle/multiwalled carbon nanotubes (Ag/MWNTs) coated on a polyacrylonitrile (PAN) hollow fiber membrane, Ag/ MWNTs/PAN, has been developed.