M
Matthias Haase
Researcher at University of Düsseldorf
Publications - 43
Citations - 1018
Matthias Haase is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Aldosterone & Adrenal cortex. The author has an hindex of 13, co-authored 42 publications receiving 844 citations. Previous affiliations of Matthias Haase include Dresden University of Technology.
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Journal ArticleDOI
Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors
Gerald Goh,Ute I. Scholl,James M. Healy,Murim Choi,Manju L. Prasad,Carol Nelson-Williams,John W. Kunstman,Reju Korah,Anna-Carinna Suttorp,Dimo Dietrich,Matthias Haase,Holger S. Willenberg,Peter Stålberg,Per Hellman,Göran Åkerström,Peyman Björklund,Tobias Carling,Richard P. Lifton +17 more
TL;DR: Different mechanisms underlying adrenal cortisol-producing tumors are defined, including PKA activity induces cortisol production and cell proliferation, providing a mechanism for tumor development.
Journal ArticleDOI
Whole-Exome Sequencing Characterizes the Landscape of Somatic Mutations and Copy Number Alterations in Adrenocortical Carcinoma
C. Christofer Juhlin,C. Christofer Juhlin,Gerald Goh,James M. Healy,Annabelle L. Fonseca,Ute I. Scholl,Adam Stenman,John W. Kunstman,Taylor C. Brown,John D. Overton,Shrikant Mane,Carol Nelson-Williams,Martin Bäckdahl,Anna Carinna Suttorp,Matthias Haase,Murim Choi,Joseph Schlessinger,David L. Rimm,Anders Höög,Manju L. Prasad,Reju Korah,Catharina Larsson,Richard P. Lifton,Tobias Carling +23 more
TL;DR: Overall, mutations in either TP53 or CTNNB1 as well as focal CNAs at the ZNRF3 or TERT loci denote mutually exclusive events, suggesting separate mechanisms underlying the development of these tumors.
Journal ArticleDOI
An LC-MS/MS method for steroid profiling during adrenal venous sampling for investigation of primary aldosteronism.
Mirko Peitzsch,Tanja Dekkers,Matthias Haase,Fred C.G.J. Sweep,Ivo Quack,Gerald Antoch,Gabriele Siegert,Jacques W.M. Lenders,Jaap Deinum,Holger S. Willenberg,Graeme Eisenhofer +10 more
TL;DR: The LC-MS/MS assay offers profiling of 13 other adrenal steroids, providing a potentially useful method for the clinical work-up of patients with primary aldosteronism, and larger AV/pV ratios of several steroids compared to cortisol suggest more sensitive alternatives to the latter for assessing positioning of AV sampling catheters.
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Mass Spectrometry–Based Adrenal and Peripheral Venous Steroid Profiling for Subtyping Primary Aldosteronism
Graeme Eisenhofer,Tanja Dekkers,Mirko Peitzsch,Anna Dietz,Martin Bidlingmaier,Marcus Treitl,Tracy Ann Williams,Stefan R. Bornstein,Matthias Haase,L. C. Rump,Holger S. Willenberg,Felix Beuschlein,Jaap Deinum,Jacques W.M. Lenders,Jacques W.M. Lenders,Martin Reincke +15 more
TL;DR: LC-MS/MS-based steroid profiling during AVS achieves higher aldosterone lateralization ratios in patients with APAs than immunoassay, and enables multiple measures for discriminating unilateral from bilateral ald testosterone excess, with potential use of peripheral plasma for subtype classification.
Journal ArticleDOI
PRKACA mutations in cortisol-producing adenomas and adrenal hyperplasia - a single-center study of 60 cases
Anne Thiel,Anna-Carinna Reis,Matthias Haase,Gerald Goh,Matthias Schott,Holger S. Willenberg,Ute I. Scholl +6 more
TL;DR: Somatic mutations in PRKACA(L206R) is present not only in adenomas, but also in unilateral hyperplasia and is associated with more severe autonomous cortisol secretion, and was associated with younger age, overt Cushing's syndrome, and higher cortisol levels vs non-PRKACA-mutant or CTNNB1-mutants.