Tanja Dekkers

TL;DR: Exome sequencing of zona glomerulosa–like APAs identifies nine with somatic mutations in either ATP1A1, encoding the Na+/K+ ATPase α1 subunit, or CACNA1D, encoding Cav1.3, which caused inward leak currents under physiological conditions and induced a shift of voltage-dependent gating to more negative voltages, suppressed inactivation or increased currents.

TL;DR: It is demonstrated that it is pointless to claim low or high prevalence of primary aldosteronism based on published reports, and the findings urge for a prevalence study whose design takes into account the factors identified in the meta-regression analysis.

TL;DR: A non-significant mean difference of 0·05 (95% CI -0·04 to 0·13) in quality-adjusted life-years (QALYs) was found to the advantage of the AVS group, associated with a significant increase in mean health-care costs of €2285 per patient.

TL;DR: It is indicated that glucocorticoid cosecretion is frequently found in primary aldosteronism and contributes to associated metabolic risk, and mineralocortioid receptor antagonist therapy alone may not be sufficient to counteract adverse metabolic risk in medically treated patients with primary aldononism.

TL;DR: The LC-MS/MS assay offers profiling of 13 other adrenal steroids, providing a potentially useful method for the clinical work-up of patients with primary aldosteronism, and larger AV/pV ratios of several steroids compared to cortisol suggest more sensitive alternatives to the latter for assessing positioning of AV sampling catheters.