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Shannon T. Bailey
Researcher at Harvard University
Publications - 26
Citations - 8542
Shannon T. Bailey is an academic researcher from Harvard University. The author has contributed to research in topics: Transcription factor & Breast cancer. The author has an hindex of 17, co-authored 22 publications receiving 8044 citations. Previous affiliations of Shannon T. Bailey include University of Pennsylvania & Brigham and Women's Hospital.
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Journal ArticleDOI
The hormone resistin links obesity to diabetes
Claire M. Steppan,Shannon T. Bailey,Savitha Bhat,Elizabeth J. Brown,Ronadip R. Banerjee,Christopher M. Wright,Hiralben R. Patel,Rexford S. Ahima,Mitchell A. Lazar +8 more
TL;DR: It is shown that adipocytes secrete a unique signalling molecule, which is named resistin (for resistance to insulin), which circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity.
Journal ArticleDOI
A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response.
Chinyu G. Su,Xiaoming Wen,Shannon T. Bailey,Wen Jiang,Shamina M. Rangwala,Sue A. Keilbaugh,Anne Flanigan,Sreekant Murthy,Mitchell A. Lazar,Gary D. Wu +9 more
TL;DR: It is reported here that PPAR-gamma ligands dramatically attenuate cytokine gene expression in colon cancer cell lines by inhibiting the activation of nuclear factor-kappaB via an IkappaB-alpha-dependent mechanism, and thiazolidinedione ligands for PPARS markedly reduce colonic inflammation in a mouse model of IBD.
Journal ArticleDOI
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo
Jae-Hyuck Shim,Changchun Xiao,Amber E. Paschal,Shannon T. Bailey,Ping Rao,Matthew S. Hayden,Ki-Young Lee,Crystal Bussey,Michael Steckel,Nobuyuki Tanaka,Gen Yamada,Shizuo Akira,Kunihiro Matsumoto,Sankar Ghosh +13 more
TL;DR: The studies suggests that TAK1 acts as an upstream activating kinase for IKKbeta and JNK, but not IKKalpha, revealing an unexpectedly specific role of TAK 1 in inflammatory signaling pathways.
Journal ArticleDOI
Nucleosome dynamics define transcriptional enhancers.
Housheng Hansen He,Clifford A. Meyer,Hyunjin Shin,Shannon T. Bailey,Gang Wei,Qianben Wang,Qianben Wang,Yong Zhang,Yong Zhang,Kexin Xu,Min Ni,Mathieu Lupien,Mathieu Lupien,Piotr A. Mieczkowski,Jason D. Lieb,Keji Zhao,Myles Brown,X. Shirley Liu +17 more
TL;DR: In this article, the authors performed genome-wide mapping of epigenetically marked nucleosomes to determine their position both near transcription start sites and at distal regulatory elements, including enhancers.
Journal ArticleDOI
Interdomain communication regulating ligand binding by PPAR-γ
Dalei Shao,Shamina M. Rangwala,Shannon T. Bailey,Samuel L. Krakow,Mauricio J. Reginato,Mitchell A. Lazar +5 more
TL;DR: The ability of the A/B domain to regulate ligand binding has important implications for the evaluation and mechanism of action of potentially therapeutic ligands that bind PPAR-γ and that are likely to extend to other members of the nuclear-receptor superfamily.