M
Maximilian Hatting
Researcher at RWTH Aachen University
Publications - 34
Citations - 989
Maximilian Hatting is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Liver injury & Internal medicine. The author has an hindex of 13, co-authored 25 publications receiving 624 citations. Previous affiliations of Maximilian Hatting include Harvard University.
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Journal ArticleDOI
Insulin regulation of gluconeogenesis.
TL;DR: In individuals with compromised insulin signaling, such as insulin resistance in type 2 diabetes, insulin fails to suppress hepatic gluconeogenesis, even in the fed state; hence, an insight into these insulin‐moderated pathways is critical for therapeutic purposes.
Journal ArticleDOI
Loss of Caspase-8 Protects Mice Against Inflammation-Related Hepatocarcinogenesis but Induces Non-Apoptotic Liver Injury
Christian Liedtke,Jörg Martin Bangen,Julia Freimuth,Naiara Beraza,D Lambertz,Francisco Javier Cubero,Maximilian Hatting,KR Karlmark,Konrad L. Streetz,Gabriele A. Krombach,Frank Tacke,Nikolaus Gassler,Dieter Riethmacher,Christian Trautwein +13 more
TL;DR: Inhibition of Casp8 protects mice from hepatocarcinogenesis following chronic liver injury mediated by apoptosis of hepatocytes but can activate RIP-mediated necrosis in an inflammatory environment.
Journal ArticleDOI
Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis
Lijun Liao,Kai Markus Schneider,Eric J. C. Gálvez,M. Frissen,Hanns-Ulrich Marschall,Huan Su,Maximilian Hatting,Annika Wahlström,Johannes Haybaeck,Johannes Haybaeck,Philip Puchas,Antje Mohs,J Peng,Ina Bergheim,Anika Nier,J Hennings,J Reißing,Henning W. Zimmermann,Thomas Longerich,Till Strowig,Christian Liedtke,Francisco Javier Cubero,Christian Trautwein +22 more
TL;DR: Investigating the functional role of gut–liver crosstalk for CLD in the murine Mdr2 knockout (Mdr2−/−) model resembling human primary sclerosing cholangitis found MDR2-associated cholestasis triggers intestinal dysbiosis, which contributes to higher liver injury.
Journal ArticleDOI
Hepatocyte caspase‐8 is an essential modulator of steatohepatitis in rodents
Maximilian Hatting,G Zhao,Fabienne Schumacher,Gernot Sellge,Malika Al Masaoudi,Nikolaus Gaβler,Mark V. Boekschoten,Michael Müller,Christian Liedtke,Francisco Javier Cubero,Christian Trautwein +10 more
TL;DR: Lack of Casp8 expression in hepatocytes reduced the MCD‐dependent increase in apoptosis and decreased expression of proinflammatory cytokines as well as hepatic infiltration, leading to a reduction in the progression of liver fibrosis in Casp 8Δhep livers.
Journal ArticleDOI
Hepatocyte specific deletion of c-Met leads to the development of severe non-alcoholic steatohepatitis in mice
Daniela C. Kroy,Fabienne Schumacher,Pierluigi Ramadori,Maximilian Hatting,Ina Bergheim,Nikolaus Gassler,Mark V. Boekschoten,Michael Müller,Konrad L. Streetz,Christian Trautwein +9 more
TL;DR: Gene array analysis demonstrated that genes involved in fatty acid metabolism were strongly upregulated in c-MetΔ(hepa) livers correlating with higher amounts of hepatic free fatty acids, which correlated with an enhanced progression of liver fibrosis.