M
Mazahir T. Hasan
Researcher at Max Planck Society
Publications - 44
Citations - 4910
Mazahir T. Hasan is an academic researcher from Max Planck Society. The author has contributed to research in topics: Gene & Population. The author has an hindex of 25, co-authored 40 publications receiving 4556 citations. Previous affiliations of Mazahir T. Hasan include Charité & Ikerbasque.
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Journal ArticleDOI
Exploring the sequence space for tetracycline-dependent transcriptional activators: Novel mutations yield expanded range and sensitivity
Stefanie Urlinger,Udo Baron,Marion Thellmann,Mazahir T. Hasan,Hermann Bujard,Wolfgang Hillen +5 more
TL;DR: Five new rtTAs were identified, of which two have greatly improved properties, and the most promising new transactivator, rtTA2(S)-M2, functions at a 10-fold lower Dox concentration than rTTA, is more stable in eukaryotic cells, and causes no background expression in the absence of Dox.
Journal ArticleDOI
Two-photon imaging to a depth of 1000 µm microm in living brains by use of a Ti:Al2O3 regenerative amplifier
TL;DR: It is shown that two-photon fluorescence images can be obtained throughout almost the entire gray matter of the mouse neocortex by using optically amplified femtosecond pulses.
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Complementation Cloning of S2P, a Gene Encoding a Putative Metalloprotease Required for Intramembrane Cleavage of SREBPs
Robert B. Rawson,Nikolai G. Zelenski,Deepak Nijhawan,Jin Ye,Juro Sakai,Mazahir T. Hasan,Ta-Yuan Chang,Michael S. Brown,Joseph L. Goldstein +8 more
TL;DR: S2P defines a new family of polytopic membrane proteins that contain an HEXXH sequence characteristic of zinc metalloproteases that cleaves proteins within transmembrane segments.
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IKK mediates ischemia-induced neuronal death.
Oliver Herrmann,Bernd Baumann,Rossana De Lorenzi,Sajjad Muhammad,Wen Zhang,Wen Zhang,Jens Kleesiek,Max Malfertheiner,Martin Köhrmann,Ioana Potrovita,Ira Maegele,Cordian Beyer,James R. Burke,Mazahir T. Hasan,Hermann Bujard,Thomas Wirth,Manolis Pasparakis,Markus Schwaninger +17 more
TL;DR: It is shown that IKK is activated in a mouse model of stroke, indicating a key function of IKK in ischemic brain damage and suggesting a potential role for IKK inhibitors in stroke therapy.
Journal ArticleDOI
Functional fluorescent Ca2+ indicator proteins in transgenic mice under TET control.
Mazahir T. Hasan,Rainer W. Friedrich,Thomas Euler,Matthew E. Larkum,Günter Giese,Matthias Both,Jens Duebel,Jack Waters,Hermann Bujard,Oliver Griesbeck,Roger Y. Tsien,Takeharu Nagai,Atsushi Miyawaki,Winfried Denk +13 more
TL;DR: It is found that stimuli known to increase intracellular calcium concentration (somatically triggered action potentials and synaptic and sensory stimulation) can cause substantial and rapid changes in FCIP fluorescence of inverse pericam and camgaroo-2.