Showing papers in "Molecular Cell in 1997"

TL;DR: It is discovered that 14-3-3σ is strongly induced by γ irradiation and other DNA-damaging agents, and mediated by a p53-responsive element located 1.8 kb upstream of its transcription start site.

TL;DR: The results suggest that the discoidin-related DDR tyrosine kinases are novel collagen receptors with the potential to control cellular responses to the extracellular matrix.

TL;DR: It is shown here that normal FMRP associates with elongating polyribosomes via large mRNP particles, implying that the mechanism of the severe phenotype in the I304N patient lies in the sequestration of bound mRNAs in nontranslatable mR NP particles.

TL;DR: It is reported that the collagens serve as ligands for the previously orphan family of discoidin domain-containing receptor-like tyrosine kinases, and this finding seems likely to change prevailing views about the mechanisms by which cells perceive and respond to the extracellular matrix.

TL;DR: S2P defines a new family of polytopic membrane proteins that contain an HEXXH sequence characteristic of zinc metalloproteases that cleaves proteins within transmembrane segments.

TL;DR: Results indicate that recruitment of histone acetyltransferase activity of PCAF by MyoD, through p300/CBP, is crucial for activation of the myogenic program.

TL;DR: These studies provide a direct biochemical demonstration of the importance of the structure and function of natural multicomponent transcriptional enhancer complexes in gene regulation.

TL;DR: Visualization of the primary transcripts shows that the level of transcription is proportional to the frequency of transcriptional periods and that the position of the beta-globin gene in the locus is important for correct developmental regulation.

TL;DR: It is shown that vaccinia topoisomerase, a eukaryotic type IB enzyme, catalyzes site-specific endoribonucleolytic cleavage of an RNA-containing strand, suggesting potential roles for topoisomersases in RNA processing.

TL;DR: Interestingly, once nucleosome remodeling by the DNA binding factor is accomplished, a high level of NURF activity is not continuously required for recruitment of the general transcriptional machinery and transcription for at least 100 nucleotides.

TL;DR: It is shown that the U12-dependent splicing system can splice introns with /GU and AG/ termini and that such introns occur naturally and are evolutionarily conserved.

TL;DR: The structure of the complex suggests that part of the membrane anchor of the receptor can interact with a hinge region of DT, and provides a basis for altering the binding specificity of the toxin, and may also serve as a model for other EGF-receptor interactions.

TL;DR: It is found that the helical M domain is inherently flexible, which results in a global destabilization of Fth, which is prevented by binding of 4.5S RNA.

TL;DR: It is suggested that the tricorn capsid, in addition to its intrinsic proteolytic activity, serves as the organizing center of a multienzyme complex.

TL;DR: The results support the view that stabilization of RNAP at the promoter over a threshold level leads to repression, and the position of protein p4 relative to that ofRNAP, which is different at each promoter, does not dictate the outcome of the interaction.

TL;DR: The purpose of Molecular Cell is to make it possible for us to publish more papers in the burgeoning (if not all-encompassing) field of molecular biology, and to offer a forum of high visibility and unquestioned quality that will extend the authors' capacity to address the important issues in molecular biology.

TL;DR: The three-dimensional structure of the thermostable alpha-amylase from Bacillus licheniformis has been determined by the multiple isomorphous replacement method of X-ray crystallography as mentioned in this paper.