Megan J. Larmore

TL;DR: Ex vivo modeling of primary airway epithelial cells in organotypic co-culture with mast cells has shown that epithelial-derived IL-33 uniquely induced type-2 cytokines in mast cells, which regulated the expression of epithelial IL33 in a feedforward loop.

TL;DR: It is demonstrated that ovulatory dysfunction is an additional mechanism underlying the age-related loss of fertility beyond the reduction of egg quantity and quality, and aberrant morphology of the ovarian surface epithelium (OSE).

TL;DR: It is found that interleukin (IL)-33 and IL-5 additively increased cysteinyl leukotriene (CysLT) production by eosinophils and that the CysLT LTC4 along with IL-33 increased IL13 expression in mast cells and altered their protease profile.

TL;DR: This study indicates that HA deposition in islets occurs early in type 1 diabetes and prior to insulitis, and points to a potential role of HA in triggering islet immune-cell infiltration and the promotion of INSulitis.

TL;DR: It is found that expression of endothelial dysfunction marker genes is markedly increased in diabetic mice, and empagliflozin treatment was more effective than metformin alone, with a combination of the two drugs demonstrating the greatest effects.