M
Matthew C. Altman
Researcher at University of Washington
Publications - 73
Citations - 994
Matthew C. Altman is an academic researcher from University of Washington. The author has contributed to research in topics: Medicine & Asthma. The author has an hindex of 13, co-authored 51 publications receiving 537 citations. Previous affiliations of Matthew C. Altman include University of Washington Medical Center & Benaroya Research Institute.
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Journal ArticleDOI
Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children.
Matthew C. Altman,Matthew C. Altman,Michelle A. Gill,Elizabeth Whalen,Denise C. Babineau,Baomei Shao,Andrew H. Liu,Brett Jepson,Rebecca S. Gruchalla,George T. O'Connor,Jacqueline A. Pongracic,Carolyn M. Kercsmar,Gurjit K. Khurana Hershey,Edward M. Zoratti,Christine Cole Johnson,Stephen J. Teach,Meyer Kattan,Leonard B. Bacharier,Avraham Beigelman,Steve M. Sigelman,Scott R. Presnell,James E. Gern,Peter J. Gergen,Lisa M. Wheatley,Alkis Togias,William W. Busse,Daniel J. Jackson +26 more
TL;DR: This work introduces an in vivo molecular platform to investigate, in a clinical setting, both the mechanisms of disease pathogenesis and therapeutic targets to modify exacerbations by identifying repertoires of cellular transcriptional pathways that lead to and underlie distinct patterns of asthma exacerbation.
Journal ArticleDOI
Ruxolitinib partially reverses functional natural killer cell deficiency in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations
Alexander Vargas Hernandez,Alexander Vargas Hernandez,Emily M. Mace,Emily M. Mace,Ofer Zimmerman,Christa S. Zerbe,Alexandra F. Freeman,Sergio D. Rosenzweig,Jennifer W. Leiding,Troy Torgerson,Matthew C. Altman,Edith Schussler,Charlotte Cunningham-Rundles,Ivan K. Chinn,Ivan K. Chinn,Alexandre F. Carisey,Alexandre F. Carisey,Imelda C. Hanson,Nicholas L. Rider,Nicholas L. Rider,Steven M. Holland,Jordan S. Orange,Jordan S. Orange,Lisa R. Forbes,Lisa R. Forbes +24 more
TL;DR: Modulation of increased STAT1 phosphorylation with ruxolitinib is an important option for therapeutic intervention in patients with STAT1 GOF mutations, and properly regulated STAT1 signaling is critical for NK cell maturation and function.
Journal ArticleDOI
A narrow repertoire of transcriptional modules responsive to pyogenic bacteria is impaired in patients carrying loss-of-function mutations in MYD88 or IRAK4
Laia Alsina,Laia Alsina,Elisabeth Israelsson,Matthew C. Altman,Kristen K. Dang,Pegah Ghandil,Pegah Ghandil,Laura Israel,Laura Israel,Horst von Bernuth,Horst von Bernuth,Horst von Bernuth,Nicole Baldwin,Huanying Qin,Zongbo Jin,Romain Banchereau,Esperanza Anguiano,Alexei Ionan,Laurent Abel,Laurent Abel,Anne Puel,Anne Puel,Anne Puel,Capucine Picard,Virginia Pascual,Jean-Laurent Casanova,Damien Chaussabel,Damien Chaussabel,Damien Chaussabel +28 more
TL;DR: A systems approach is introduced for the global assessment of innate immune responses and the characterization of human primary immunodeficiencies following in vitro exposure of patients' blood to agonists of Toll-like receptors and receptors for interleukin 1 and to whole pathogens.
Journal ArticleDOI
Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy.
Jana Blazkova,Sarthak Gupta,Yudong Liu,Brice Gaudilliere,Edward A. Ganio,Christopher R. Bolen,Ron Saar-Dover,Gabriela K. Fragiadakis,Martin S. Angst,Sarfaraz Hasni,Nima Aghaeepour,David K. Stevenson,Nicole Baldwin,Esperanza Anguiano,Damien Chaussabel,Matthew C. Altman,Mariana J. Kaplan,Mark M. Davis,David Furman +18 more
TL;DR: The findings show novel sex differences in innate immunity and identify a common neutrophil signature in males and in pregnant women, which is found at higher levels in young but not older males compared with females.