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Rebecca L. Hull
Researcher at University of Washington
Publications - 73
Citations - 11291
Rebecca L. Hull is an academic researcher from University of Washington. The author has contributed to research in topics: Islet & Amyloid. The author has an hindex of 33, co-authored 66 publications receiving 10095 citations. Previous affiliations of Rebecca L. Hull include Veterans Health Administration.
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Journal ArticleDOI
Mechanisms linking obesity to insulin resistance and type 2 diabetes
TL;DR: In obese individuals, adipose tissue releases increased amounts of non-esterified fatty acids, glycerol, hormones, pro-inflammatory cytokines and other factors that are involved in the development of insulin resistance.
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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
Seth L. Masters,Aisling Dunne,Shoba L. Subramanian,Rebecca L. Hull,Gillian M. Tannahill,Fiona A. Sharp,Christine Becker,Luigi Franchi,Eiji Yoshihara,Zhe Chen,Niamh Mullooly,Lisa A. Mielke,James Harris,Rebecca C. Coll,Kingston H. G. Mills,K. Hun Mok,Philip Newsholme,Gabriel Núñez,Junji Yodoi,Steven E. Kahn,Ed C. Lavelle,Luke A. J. O'Neill +21 more
TL;DR: It is shown that oligomers of islet amyloid polypeptide (IAPP), a protein that formsAmyloid deposits in the pancreas during type 2 diabetes, triggered the NLRP3 inflammasome and generated mature IL-1β.
Journal ArticleDOI
Intra-Abdominal Fat Is a Major Determinant of the National Cholesterol Education Program Adult Treatment Panel III Criteria for the Metabolic Syndrome
Darcy B. Carr,Kristina M. Utzschneider,Rebecca L. Hull,Keiichi Kodama,Barbara M. Retzlaff,John D. Brunzell,Jane B. Shofer,Brian Fish,Robert H. Knopp,Steven E. Kahn +9 more
TL;DR: Although insulin resistance and central body fat are both associated with the metabolic syndrome, IAF is independently associated with all of the criteria, suggesting that it may have a pathophysiological role.
Journal ArticleDOI
Islet amyloid: a critical entity in the pathogenesis of type 2 diabetes.
TL;DR: Interventions to prevent islet amyloid formation are emerging, with peptide and small molecule inhibitors being developed that could lead to a preservation of beta-cell mass and amelioration of the islet lesion in type 2 diabetes.
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The Concurrent Accumulation of Intra-Abdominal and Subcutaneous Fat Explains the Association Between Insulin Resistance and Plasma Leptin Concentrations: Distinct Metabolic Effects of Two Fat Compartments
Miriam Cnop,Melinda J. Landchild,Josep Vidal,Peter J. Havel,Negar G. Knowles,Darcy R. Carr,Feng Wang,Rebecca L. Hull,Edward J. Boyko,Barbara M. Retzlaff,C. E. Walden,Robert H. Knopp,Steven E. Kahn +12 more
TL;DR: It is concluded that the concurrent increase in these two metabolically distinct fat compartments is a major explanation for the association between insulin resistance and elevated circulating leptin concentrations in lean and obese subjects.