M
Megan Simpkinson
Researcher at Cedars-Sinai Medical Center
Publications - 4
Citations - 1052
Megan Simpkinson is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: C9orf72 & C9orf72 Protein. The author has an hindex of 4, co-authored 4 publications receiving 939 citations.
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Journal ArticleDOI
Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion
Dhruv Sareen,Jacqueline G. O’Rourke,Pratap Meera,A. K. M. G. Muhammad,Sharday Grant,Megan Simpkinson,Shaughn Bell,Sharon Carmona,Loren Ornelas,Anais Sahabian,Tania F. Gendron,Leonard Petrucelli,Michael Baughn,John Ravits,Matthew B. Harms,Frank Rigo,C. Frank Bennett,Thomas S. Otis,Clive N. Svendsen,Robert H. Baloh +19 more
TL;DR: Findings support the idea that the buildup of “toxic” RNA containing the GGGGCC repeat contributes to the death of motor neurons in ALS, and suggest that antisense oligonucleotides targeting this transcript may be a strategy for treating ALS patients with the C9ORF72 repeat expansion.
Journal ArticleDOI
C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD.
Jacqueline G. O’Rourke,Laurent P. Bogdanik,A. K. M. G. Muhammad,Tania F. Gendron,Kevin J. Kim,Andrew Austin,Janet Cady,Elaine Liu,Jonah Zarrow,Sharday Grant,Ritchie Ho,Shaughn Bell,Sharon Carmona,Megan Simpkinson,Deepti Lall,Kathryn Wu,Lillian M. Daughrity,Dennis W. Dickson,Matthew B. Harms,Leonard Petrucelli,Edward B. Lee,Cathleen M. Lutz,Robert H. Baloh +22 more
TL;DR: In this article, the authors report transgenic mice carrying a bacterial artificial chromosome (BAC) containing the full human C9orf72 gene with either a normal allele (15 repeats) or disease-associated expansion (∼100-1,000 repeats; C9-BACexp).
Journal Article
C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD (P4.001)
Robert H. Baloh,Jacqueline G. O’Rourke,Shaughn Bell,Laurent Bogdonik,A. K. M. G. Muhammad,Tania F. Gendron,Kevin J. Kim,Andrew Austin,Janet Cady,Elaine Liu,Jonah Zarrow,Sharday Grant,Ritchie Ho,Sharon Carmona,Megan Simpkinson,Kathryn Wu,Lillian M. Daughrity,Dennis W. Dickson,Matthew B. Harms,Leonard Petrucelli,Cathleen M. Lutz +20 more
TL;DR: Transgenic mice carrying a bacterial artificial chromosome containing the full human C9orf72 gene with either a normal allele (15 repeats) or disease-associated expansion (∼100-1,000 repeats; C9-BACexp) are reported, supporting the hypothesis that RNA foci and RAN dipeptides occur presymptomatically and are not sufficient to drive neurodegeneration in mice at levels seen in patients.
Journal ArticleDOI
Cell transplantation strategies for acquired and inherited disorders of peripheral myelin.
A. K. M. G. Muhammad,Kevin J. Kim,Irina Epifantseva,Arwin Aghamaleky‐Sarvestany,Megan Simpkinson,Sharon Carmona,Jesse Landeros,Shaughn Bell,John Svaren,Robert H. Baloh +9 more
TL;DR: To investigate transplantation of rat Schwann cells or human iPSC‐derived neural crest cells and derivatives into models of acquired and inherited peripheral myelin damage.