S
Sharday Grant
Researcher at Cedars-Sinai Medical Center
Publications - 8
Citations - 1183
Sharday Grant is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Enantioselective synthesis & Catalysis. The author has an hindex of 6, co-authored 8 publications receiving 1060 citations. Previous affiliations of Sharday Grant include Scripps College & University of Zurich.
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Journal ArticleDOI
Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion
Dhruv Sareen,Jacqueline G. O’Rourke,Pratap Meera,A. K. M. G. Muhammad,Sharday Grant,Megan Simpkinson,Shaughn Bell,Sharon Carmona,Loren Ornelas,Anais Sahabian,Tania F. Gendron,Leonard Petrucelli,Michael Baughn,John Ravits,Matthew B. Harms,Frank Rigo,C. Frank Bennett,Thomas S. Otis,Clive N. Svendsen,Robert H. Baloh +19 more
TL;DR: Findings support the idea that the buildup of “toxic” RNA containing the GGGGCC repeat contributes to the death of motor neurons in ALS, and suggest that antisense oligonucleotides targeting this transcript may be a strategy for treating ALS patients with the C9ORF72 repeat expansion.
Journal ArticleDOI
C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD.
Jacqueline G. O’Rourke,Laurent P. Bogdanik,A. K. M. G. Muhammad,Tania F. Gendron,Kevin J. Kim,Andrew Austin,Janet Cady,Elaine Liu,Jonah Zarrow,Sharday Grant,Ritchie Ho,Shaughn Bell,Sharon Carmona,Megan Simpkinson,Deepti Lall,Kathryn Wu,Lillian M. Daughrity,Dennis W. Dickson,Matthew B. Harms,Leonard Petrucelli,Edward B. Lee,Cathleen M. Lutz,Robert H. Baloh +22 more
TL;DR: In this article, the authors report transgenic mice carrying a bacterial artificial chromosome (BAC) containing the full human C9orf72 gene with either a normal allele (15 repeats) or disease-associated expansion (∼100-1,000 repeats; C9-BACexp).
Journal Article
C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD (P4.001)
Robert H. Baloh,Jacqueline G. O’Rourke,Shaughn Bell,Laurent Bogdonik,A. K. M. G. Muhammad,Tania F. Gendron,Kevin J. Kim,Andrew Austin,Janet Cady,Elaine Liu,Jonah Zarrow,Sharday Grant,Ritchie Ho,Sharon Carmona,Megan Simpkinson,Kathryn Wu,Lillian M. Daughrity,Dennis W. Dickson,Matthew B. Harms,Leonard Petrucelli,Cathleen M. Lutz +20 more
TL;DR: Transgenic mice carrying a bacterial artificial chromosome containing the full human C9orf72 gene with either a normal allele (15 repeats) or disease-associated expansion (∼100-1,000 repeats; C9-BACexp) are reported, supporting the hypothesis that RNA foci and RAN dipeptides occur presymptomatically and are not sufficient to drive neurodegeneration in mice at levels seen in patients.
Journal ArticleDOI
Synthesis of 3‐Fluoro‐3‐aryl Oxindoles: Direct Enantioselective α Arylation of Amides
Linglin Wu,Laura Falivene,Emma Drinkel,Sharday Grant,Anthony Linden,Luigi Cavallo,Luigi Cavallo,Reto Dorta,Reto Dorta +8 more
TL;DR: The enantioselective construction of a C-F bond is based on an asymmetric α-arylation protocol and allows the preparation of the title compounds with good yields and excellent enantiorelectivities.
Journal ArticleDOI
Electron‐Withdrawing, Biphenyl‐2,2′‐diol‐Based Compounds for Asymmetric Catalysis
Elisa G. Gutierrez,Eric J. Moorhead,Eva H. Smith,Vivian S. Lin,Laura K. G. Ackerman,Claire E. Knezevic,Victoria L. Sun,Sharday Grant,Anna G. Wenzel +8 more
TL;DR: In this paper, a chiral O,O-biphenyl-2,2′-diyl phosphoramidothioate was used as a catalysts for the Friedel-Crafts alkylation of indole.