S
Sharon Carmona
Researcher at Cedars-Sinai Medical Center
Publications - 6
Citations - 1582
Sharon Carmona is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Neurodegeneration & C9orf72. The author has an hindex of 6, co-authored 6 publications receiving 1341 citations.
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Journal ArticleDOI
Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion
Dhruv Sareen,Jacqueline G. O’Rourke,Pratap Meera,A. K. M. G. Muhammad,Sharday Grant,Megan Simpkinson,Shaughn Bell,Sharon Carmona,Loren Ornelas,Anais Sahabian,Tania F. Gendron,Leonard Petrucelli,Michael Baughn,John Ravits,Matthew B. Harms,Frank Rigo,C. Frank Bennett,Thomas S. Otis,Clive N. Svendsen,Robert H. Baloh +19 more
TL;DR: Findings support the idea that the buildup of “toxic” RNA containing the GGGGCC repeat contributes to the death of motor neurons in ALS, and suggest that antisense oligonucleotides targeting this transcript may be a strategy for treating ALS patients with the C9ORF72 repeat expansion.
Journal ArticleDOI
C9orf72 is required for proper macrophage and microglial function in mice
Jacqueline G. O’Rourke,Laurent P. Bogdanik,Alberto Yáñez,Deepti Lall,Andrea J. Wolf,A. K. M. G. Muhammad,Ritchie Ho,Sharon Carmona,Jean-Philippe Vit,Jonah Zarrow,Kevin J. Kim,Shaughn Bell,Matthew B. Harms,Timothy M. Miller,C. A. Dangler,David M. Underhill,Helen S. Goodridge,Cathleen M. Lutz,Robert H. Baloh +18 more
TL;DR: It is found that two independent mouse lines lacking the C9orf72 ortholog in all tissues developed normally and aged without motor neuron disease, and altered microglial function may contribute to neurodegeneration in C 9orf72 expansion carriers.
Journal ArticleDOI
C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD.
Jacqueline G. O’Rourke,Laurent P. Bogdanik,A. K. M. G. Muhammad,Tania F. Gendron,Kevin J. Kim,Andrew Austin,Janet Cady,Elaine Liu,Jonah Zarrow,Sharday Grant,Ritchie Ho,Shaughn Bell,Sharon Carmona,Megan Simpkinson,Deepti Lall,Kathryn Wu,Lillian M. Daughrity,Dennis W. Dickson,Matthew B. Harms,Leonard Petrucelli,Edward B. Lee,Cathleen M. Lutz,Robert H. Baloh +22 more
TL;DR: In this article, the authors report transgenic mice carrying a bacterial artificial chromosome (BAC) containing the full human C9orf72 gene with either a normal allele (15 repeats) or disease-associated expansion (∼100-1,000 repeats; C9-BACexp).
Journal Article
C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD (P4.001)
Robert H. Baloh,Jacqueline G. O’Rourke,Shaughn Bell,Laurent Bogdonik,A. K. M. G. Muhammad,Tania F. Gendron,Kevin J. Kim,Andrew Austin,Janet Cady,Elaine Liu,Jonah Zarrow,Sharday Grant,Ritchie Ho,Sharon Carmona,Megan Simpkinson,Kathryn Wu,Lillian M. Daughrity,Dennis W. Dickson,Matthew B. Harms,Leonard Petrucelli,Cathleen M. Lutz +20 more
TL;DR: Transgenic mice carrying a bacterial artificial chromosome containing the full human C9orf72 gene with either a normal allele (15 repeats) or disease-associated expansion (∼100-1,000 repeats; C9-BACexp) are reported, supporting the hypothesis that RNA foci and RAN dipeptides occur presymptomatically and are not sufficient to drive neurodegeneration in mice at levels seen in patients.
Journal ArticleDOI
Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model
Yueqin Zhou,Sharon Carmona,A.K.M.G. Muhammad,Shaughn Bell,Jesse Landeros,Michael Vazquez,Ritchie Ho,Antonietta Franco,Bin Lu,Gerald W. Dorn,Shaomei Wang,Cathleen M. Lutz,Robert H. Baloh +12 more
TL;DR: Using a transgenic approach, it is found that augmenting the level of MFN1 in the nervous system in vivo rescued all phenotypes in mutant MFN2R94Q-expressing mice, demonstrating that the MFN 1/MFN2 ratio is a key determinant of tissue specificity in CMT2A and indicating that augmentation of MFn1 inThe nervous system is a viable therapeutic strategy for the disease.