M
Megerditch Kiledjian
Researcher at Rutgers University
Publications - 104
Citations - 8534
Megerditch Kiledjian is an academic researcher from Rutgers University. The author has contributed to research in topics: Messenger RNA & RNA. The author has an hindex of 45, co-authored 97 publications receiving 7641 citations. Previous affiliations of Megerditch Kiledjian include Merck & Co. & Columbia University.
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Journal ArticleDOI
Reversible methylation of m6Am in the 5′ cap controls mRNA stability
Jan Mauer,Xiaobing Luo,Alexandre Blanjoie,Xinfu Jiao,Anya V. Grozhik,Deepak P. Patil,Bastian Linder,Brian F. Pickering,Jean-Jacques Vasseur,Qiuying Chen,Steven S. Gross,Olivier Elemento,Françoise Debart,Megerditch Kiledjian,Samie R. Jaffrey +14 more
TL;DR: Using a transcriptome-wide map of m6Am, it is found that m 6Am-initiated transcripts are markedly more stable than mRNAs that begin with other nucleotides and that m6 am is selectively demethylated by fat mass and obesity-associated protein (FTO).
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Primary structure and binding activity of the hnRNP U protein: binding RNA through RGG box.
TL;DR: The cloning and sequencing of a cDNA encoding the hnRNP U protein is described, the determination of its amino acid sequence and the delineation of a region in this protein that confers RNA binding are described, and an RNA binding activity is identified within the C‐terminal glycine‐rich 112 amino acids.
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Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif
TL;DR: Two complementary DNAs were isolated that encode proteins that are expressed in a variety of cell types and bind the microE5/kappa 2 motif found in both heavy and kappa light chain enhancers.
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The hDcp2 protein is a mammalian mRNA decapping enzyme.
TL;DR: The mammalian homologue of the yeast Dcp2 protein is an mRNA decapping enzyme demonstrated to contain intrinsic decapping activity, yet unlike yeast, competition of cap-binding proteins by cap analog did not influence the efficiency of decapping.
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Differential regulation of microRNA stability
Sophie Bail,Mavis R. Swerdel,Hudan Liu,Xinfu Jiao,Loyal A. Goff,Ronald P. Hart,Megerditch Kiledjian +6 more
TL;DR: It is demonstrated that although most miRNA appear to be stable, like mRNAs, miRNAs possess differential stability in human cells and it is found that miR-382, a miRNA that contributes to HIV-1 provirus latency, is unstable in cells.