M
Mei-ling A. Joiner
Researcher at Roy J. and Lucille A. Carver College of Medicine
Publications - 16
Citations - 1817
Mei-ling A. Joiner is an academic researcher from Roy J. and Lucille A. Carver College of Medicine. The author has contributed to research in topics: Ca2+/calmodulin-dependent protein kinase & Mitochondrion. The author has an hindex of 9, co-authored 15 publications receiving 1758 citations. Previous affiliations of Mei-ling A. Joiner include University of Iowa.
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Journal ArticleDOI
Correction: Corrigendum: The mitochondrial uniporter controls fight or flight heart rate increases
Yuejin Wu,Tyler P. Rasmussen,Olha M. Koval,Mei-ling A. Joiner,Duane D. Hall,Biyi Chen,Elizabeth D. Luczak,Qiongling Wang,Adam G. Rokita,Xander H.T. Wehrens,Long-Sheng Song,Mark E. Anderson +11 more
TL;DR: In Fig. 4c of this Article, the y axis values were wrongly given as 0, 20, 40, 60 and 80 in the middle and the lower panels.
Journal ArticleDOI
High-quality life extension by the enzyme peptide methionine sulfoxide reductase
Hongyu Ruan,Xiang Dong Tang,Mai-Lei Chen,Mei-ling A. Joiner,Guangrong Sun,Nathan Brot,Herbert Weissbach,Stefan H. Heinemann,Linda E. Iverson,Chun-Fang Wu,Toshinori Hoshi +10 more
TL;DR: It is reported that overexpression of the msrA gene predominantly in the nervous system markedly extends the lifespan of the fruit fly Drosophila, suggesting that oxidative damage is an important determinant of lifespan, and MSRA may be important in increasing the lifespan in other organisms including humans.
Journal ArticleDOI
Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart
Tyler P. Rasmussen,Yuejin Wu,Mei-ling A. Joiner,Olha M. Koval,Nicholas R. Wilson,Elizabeth D. Luczak,Qinchuan Wang,Biyi Chen,Zhan Gao,Zhiyong Zhu,Brett A. Wagner,Jamie Soto,Michael L. McCormick,William J. Kutschke,Robert M. Weiss,Liping Yu,Ryan L. Boudreau,E. Dale Abel,Fenghuang Zhan,Douglas R. Spitz,Garry R. Buettner,Long-Sheng Song,Leonid V. Zingman,Mark E. Anderson +23 more
TL;DR: It is shown that chronic myocardial MCU inhibition leads to previously unanticipated compensatory changes that affect cytoplasmic Ca2+ homeostasis, reprogram transcription, increase OCR, reduce performance, and prevent anticipated therapeutic responses to ischemia-reperfusion injury.
Journal ArticleDOI
Assembly of a β2‐adrenergic receptor—GluR1 signalling complex for localized cAMP signalling
Mei-ling A. Joiner,Marie-France Lisé,Eunice Y. Yuen,Angel Y F Kam,Mingxu Zhang,Duane D. Hall,Zulfiqar A. Malik,Hai Qian,Yucui Chen,Jason D. Ulrich,Alain C. Burette,Richard J. Weinberg,Ping-Yee Law,Alaa El-Husseini,Zhen Yan,Johannes W. Hell +15 more
TL;DR: Assembly of all proteins involved in the classic β2AR–cAMP cascade into a supramolecular signalling complex allows highly localized and selective regulation of one of its major target proteins.
Journal ArticleDOI
Voltage-Gated Cav1 Channels in Disorders of Vision and Hearing.
Mei-ling A. Joiner,Amy S. Lee +1 more
TL;DR: This review will cover advances in the understanding of the function of Cav1 channels at sensory ribbon synapses, and how dysregulation of these channels leads to disorders of vision and hearing.