R
Richard J. Weinberg
Researcher at University of North Carolina at Chapel Hill
Publications - 152
Citations - 17157
Richard J. Weinberg is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Postsynaptic density & Dendritic spine. The author has an hindex of 69, co-authored 151 publications receiving 15857 citations. Previous affiliations of Richard J. Weinberg include Oregon Health & Science University.
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Journal ArticleDOI
Shank, a Novel Family of Postsynaptic Density Proteins that Binds to the NMDA Receptor/PSD-95/GKAP Complex and Cortactin
Scott Naisbitt,Eunjoon Kim,Jian Cheng Tu,Bo Xiao,Carlo Sala,Juli G. Valtschanoff,Richard J. Weinberg,Paul F. Worley,Morgan Sheng +8 more
TL;DR: A novel family of postsynaptic density proteins, termed Shank, that binds via its PDZ domain to the C terminus of PSD-95-associated protein GKAP, and may function as a scaffold protein in the PSD, potentially cross-linking NMDA receptor/PSD- 95 complexes and coupling them to regulators of the actin cytoskeleton.
Journal ArticleDOI
Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3 -mutant mice
Jeffrey M. Welch,Jing Lu,Ramona M. Rodriguiz,Nicholas C. Trotta,João Peça,Jindong Ding,Catia Feliciano,Meng Chen,J. Paige Adams,Jianhong Luo,Serena M. Dudek,Richard J. Weinberg,Nicole Calakos,William C. Wetsel,Guoping Feng +14 more
TL;DR: It is shown that mice with genetic deletion of Sapap3 exhibit increased anxiety and compulsive grooming behaviour leading to facial hair loss and skin lesions; both behaviours are alleviated by a selective serotonin reuptake inhibitor.
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A β2 Adrenergic Receptor Signaling Complex Assembled with the Ca2+ Channel Cav1.2
Monika A. Davare,Vladimir Avdonin,Duane D. Hall,Erik M. Peden,Alain C. Burette,Richard J. Weinberg,Mary C. Horne,Toshinori Hoshi,Johannes W. Hell +8 more
TL;DR: Electrophysiological recordings from hippocampal neurons demonstrate highly localized signal transduction from the receptor to the channel, providing insight into how a particular receptor selectively regulates specific targets by identifying a prototypical macromolecular signaling complex.
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Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3
Xiaoming Wang,Portia A. McCoy,Ramona M. Rodriguiz,Yanzhen Pan,H. Shawn Je,Adam C. Roberts,Caroline J. Kim,Janet Berrios,Jennifer S. Colvin,Danielle Bousquet-Moore,Isabel Lorenzo,Gang Yi Wu,Richard J. Weinberg,Michael D. Ehlers,Michael D. Ehlers,Benjamin D. Philpot,Arthur L. Beaudet,William C. Wetsel,Yong-hui Jiang +18 more
TL;DR: It is concluded that loss of major Shank3 species produces biochemical, cellular and morphological changes, leading to behavioral abnormalities in mice that bear similarities to human ASD patients with SHANK3 mutations.
Journal ArticleDOI
Polarized Secretory Trafficking Directs Cargo for Asymmetric Dendrite Growth and Morphogenesis
April C. Horton,Bence Rácz,Eric Monson,Anna L. Lin,Richard J. Weinberg,Michael D. Ehlers,Michael D. Ehlers +6 more
TL;DR: A novel polarized organization of neuronal secretory trafficking is defined and a mechanistic link between directed membrane trafficking and asymmetric dendrite growth is demonstrated.