M
Melissa D. Conrad
Researcher at University of California, San Francisco
Publications - 55
Citations - 2403
Melissa D. Conrad is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 22, co-authored 48 publications receiving 1885 citations. Previous affiliations of Melissa D. Conrad include University of London & New York University.
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Journal ArticleDOI
Genetic diversity of Trichomonas vaginalis reinfection in HIV-positive women
TL;DR: T vaginalis infecting HIV+ women is not genetically distinct from T vaginalis infected with parasites from reference populations, andGenotyping/behavioural data suggest that 36% of repeat infections in HIV+Women can be attributed to treatment failure.
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Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda.
Stephen Tukwasibwe,Patrick K Tumwebaze,Melissa D. Conrad,Emmanuel Arinaitwe,Moses R. Kamya,Grant Dorsey,Samuel L. Nsobya,Bryan Greenhouse,Philip J. Rosenthal +8 more
TL;DR: Limited association between the tested polymorphisms and risk of symptomatic disease is indicated and the value of longitudinal studies for assessing associations between parasite factors and clinical outcomes is highlighted.
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Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors
Shreeya Garg,Oriana Kreutzfeld,Sevil Chelebieva,Patrick K Tumwebaze,Oswald Byaruhanga,Martin Okitwi,Stephen Orena,Thomas Katairo,Samuel L. Nsobya,Melissa D. Conrad,Ozkan Aydemir,Jennifer Legac,Alexandra E. Gould,Brett R. Bayles,Jeffrey A. Bailey,Maëlle Duffey,Gang Lin,Laura A. Kirkman,Roland A. Cooper,Philip J. Rosenthal +19 more
TL;DR: Overall, proteasome inhibitors had potent activity against P. falciparum isolates circulating in Uganda, and genetic variation in prote asome targets was uncommon.
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Deletions of pfhrp2 and pfhrp3 genes were uncommon in rapid diagnostic test-negative Plasmodium falciparum isolates from Uganda
Sam L. Nsobya,Andrew Walakira,Elizabeth Namirembe,Moses Kiggundu,Joaniter I. Nankabirwa,Emmanuel Ruhamyankaka,Emmanuel Arinaitwe,Melissa D. Conrad,Moses R. Kamya,Grant Dorsey,Philip J. Rosenthal +10 more
TL;DR: Deletions of pfhrp2/pfhrP3 in blood samples were investigated from cross-sectional surveys in 2012-13 in three regions of varied malaria transmission intensity in Uganda, finding false negative RDTs were uncommon.
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Decreased susceptibility to dihydrofolate reductase inhibitors associated with genetic polymorphisms in Ugandan Plasmodium falciparum isolates.
Oriana Kreutzfeld,Patrick K Tumwebaze,Oswald Byaruhanga,Thomas Katairo,Martin Okitwi,Stephen Orena,Stephanie A Rasmussen,Jennifer Legac,Melissa D. Conrad,Sam L. Nsobya,Ozkan Aydemir,Jeffrey A. Bailey,Maëlle Duffey,Roland A. Cooper,Philip J. Rosenthal +14 more
TL;DR: In this paper, ex vivo PfDHFR inhibitor susceptibilities of 559 isolates from Tororo and Busia districts, Uganda from 2016-2020, sequenced 383 isolates, and assessed associations between genotypes and drug susceptibility phenotypes.