M
Melissa D. Conrad
Researcher at University of California, San Francisco
Publications - 55
Citations - 2403
Melissa D. Conrad is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 22, co-authored 48 publications receiving 1885 citations. Previous affiliations of Melissa D. Conrad include University of London & New York University.
Papers
More filters
Journal ArticleDOI
Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children.
Patrick K Tumwebaze,Melissa D. Conrad,Andrew Walakira,Norbert P. LeClair,Oswald Byaruhanga,Christine Nakazibwe,Benjamin Kozak,Jessica Bloome,Jaffer Okiring,Abel Kakuru,Victor Bigira,James Kapisi,Jennifer Legac,Jiri Gut,Roland A. Cooper,Moses R. Kamya,Diane V. Havlir,Grant Dorsey,Bryan Greenhouse,Samuel L. Nsobya,Philip J. Rosenthal +20 more
TL;DR: Overall, changes in parasite sensitivity were consistent with altered selective pressures due to changing treatment practices in Uganda and may threaten the antimalarial treatment and preventive efficacies of artemether-lumefantrine and dihydroartemisinin-piperaquine, respectively.
Journal ArticleDOI
Changing Antimalarial Drug Sensitivities in Uganda.
Stephanie A Rasmussen,Frida G. Ceja,Melissa D. Conrad,Patrick K Tumwebaze,Oswald Byaruhanga,Thomas Katairo,Samuel L. Nsobya,Philip J. Rosenthal,Roland A. Cooper +8 more
TL;DR: The sensitivities of 2016 community isolates to chloroquine, amodiaquine, and piperaquine improved, and changes were accompanied by decreased prevalence of transporter mutations associated with aminoquinoline resistance and low prevalence of polymorphisms recently associated with resistance to artemisinins or p Piperaquine.
Journal ArticleDOI
The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC
Robert Verity,Ozkan Aydemir,Nicholas F Brazeau,Oliver J Watson,Nicholas J. Hathaway,Melchior Kashamuka Mwandagalirwa,Patrick W Marsh,Kyaw L. Thwai,Travis Fulton,Madeline Denton,Andrew P. Morgan,Jonathan B. Parr,Patrick K Tumwebaze,Melissa D. Conrad,Philip J. Rosenthal,Deus S. Ishengoma,Jeremiah Ngondi,Julie Gutman,Modest Mulenga,Douglas E. Norris,William J. Moss,Benedicta A. Mensah,James L. Myers-Hansen,Anita Ghansah,Antoinette K. Tshefu,Azra C. Ghani,Steven R Meshnick,Jeffrey A. Bailey,Jonathan J. Juliano +28 more
TL;DR: A high-resolution view of parasite genetic structure across a large country in Africa and provides a baseline to study how implementation programs may impact parasite populations is provided.
Journal ArticleDOI
Impact of vector control interventions on malaria transmission intensity, outdoor vector biting rates and Anopheles mosquito species composition in Tororo, Uganda.
Alex K. Musiime,David L. Smith,Maxwell Kilama,John Rek,Emmanuel Arinaitwe,Joaniter I. Nankabirwa,Moses R. Kamya,Melissa D. Conrad,Grant Dorsey,Anne M. Akol,Sarah G. Staedke,Steve W. Lindsay,J.P. Egonyu,J.P. Egonyu +13 more
TL;DR: Mass distribution of LLINs and 6 rounds of IRS dramatically decreased vector density and sporozoite rate resulting in a marked reduction in malaria transmission intensity in a historically high transmission site in Uganda.
Journal ArticleDOI
Changing Antimalarial Drug Resistance Patterns Identified by Surveillance at Three Sites in Uganda.
Patrick K Tumwebaze,Stephen Tukwasibwe,Aimee R. Taylor,Aimee R. Taylor,Melissa D. Conrad,Emmanuel Ruhamyankaka,Victor Asua,Andrew Walakira,Joaniter I. Nankabirwa,Adoke Yeka,Sarah G. Staedke,Bryan Greenhouse,Samuel L. Nsobya,Moses R. Kamya,Grant Dorsey,Philip J. Rosenthal +15 more
TL;DR: The prevalence and frequency of parasites with mutations in putative transporters previously associated with resistance to aminoquinolines, but increased sensitivity to lumefantrine, decreased markedly at all sites.