Melissa Savard

TL;DR: Blood p-tau181 can predict tau and amyloid β pathologies, differentiate Alzheimer's disease from other neurodegenerative disorders, and identify Alzheimer's Disease across the clinical continuum.

TL;DR: In this paper, the spatial propagation of microglial activation and tau accumulation colocalize in a Braak-like pattern in the living human brain, suggesting an interaction that determines disease progression.

TL;DR: In both cohorts, APOEε4 was associated in increased tau-PET uptake in the entorhinal cortex and hippocampus independently of amyloid-β, sex, age, and clinical status after multiple comparisons correction, contributing to an evolving framework in which APoeε4 has deleterious consequences in Alzheimer disease beyond its link with amyloids-β.

TL;DR: The results suggest that the hierarchical six-stage Braak model using 18F-MK-6240 imaging provides an index of early and late tau accumulation as well as disease stage in preclinical and symptomatic individuals.

TL;DR: This work examines the associations between MBI and Alzheimer's disease (AD) biomarkers in asymptomatic elderly individuals and finds no clear link between these biomarkers and dementia.