M
Meng May Chee
Researcher at University of Glasgow
Publications - 13
Citations - 1036
Meng May Chee is an academic researcher from University of Glasgow. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 12, co-authored 13 publications receiving 956 citations. Previous affiliations of Meng May Chee include Glasgow Royal Infirmary.
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Journal ArticleDOI
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
Timothy R D J Radstake,Olga Y. Gorlova,Blanca Rueda,Jose Ezequiel Martin,Behrooz Z. Alizadeh,Rogelio Palomino-Morales,Marieke J H Coenen,Madelon C. Vonk,Alexandre E. Voskuyl,Annemie J. Schuerwegh,Jasper C A Broen,Piet L. C. M. van Riel,Ruben van 't Slot,Annet Italiaander,Roel A. Ophoff,Roel A. Ophoff,Gabriela Riemekasten,Nico Hunzelmann,Carmen P. Simeon,Norberto Ortego-Centeno,Miguel A. Gonzalez-Gay,María Francisca González-Escribano,Paolo Airò,Jaap M van Laar,Ariane L. Herrick,Jane Worthington,Roger Hesselstrand,Vanessa Smith,Filip De Keyser,Fredric Houssiau,Meng May Chee,Rajan Madhok,Paul G. Shiels,Rene Westhovens,Alexander Kreuter,Hans P. Kiener,Elfride De Baere,Torsten Witte,Leonid Padykov,Lars Klareskog,Lorenzo Beretta,Rafaella Scorza,Benedicte A. Lie,Anna Maria Hoffmann-Vold,Patricia Carreira,John Varga,Monique Hinchcliff,Peter K. Gregersen,Annette Lee,Jun Ying,Younghun Han,Shih-Feng Weng,Christopher I. Amos,Fredrick M. Wigley,Laura K. Hummers,J. Lee Nelson,Sandeep K. Agarwal,Shervin Assassi,Pravitt Gourh,Filemon K. Tan,Bobby P. C. Koeleman,Frank C. Arnett,Javier Martín,Maureen D. Mayes +63 more
TL;DR: The first genome-wide association study in a population of European ancestry including a total of 2,296 individuals with SSc and 5,171 controls identified a new susceptibility locus for systemic sclerosis at CD247 (1q22–23, rs2056626).
Journal ArticleDOI
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy
Olga Y. Gorlova,Jose Ezequiel Martin,Blanca Rueda,Bobby P. C. Koeleman,Jun Ying,María Teruel,Lina-Marcela Diaz-Gallo,Jasper C A Broen,Madelon C. Vonk,Carmen P. Simeon,Behrooz Z. Alizadeh,Marieke J H Coenen,Alexandre E. Voskuyl,Annemie J. Schuerwegh,Piet L. C. M. van Riel,Marie Vanthuyne,Ruben van 't Slot,Annet Italiaander,Roel A. Ophoff,Nicolas Hunzelmann,V. Fonollosa,Norberto Ortego-Centeno,Miguel A. Gonzalez-Gay,Francisco J. García-Hernández,María F. González-EscribanoMarí,Paolo Airò,Jacob M van Laar,Jane Worthington,Roger Hesselstrand,Vanessa Smith,Filip De Keyser,Fredric Houssiau,Meng May Chee,Rajan Madhok,Paul G. Shiels,Rene Westhovens,Alexander Kreuter,Elfride De Baere,Torsten Witte,Leonid Padyukov,Annika Nordin,Raffaella Scorza,Claudio Lunardi,Benedicte A. Lie,Anna Maria Hoffmann-Vold,Øyvind Palm,García P. de la Peña Paloma,Patricia Carreira,John Varga,Monique Hinchcliff,Annette Lee,Pravitt Gourh,Christopher I. Amos,F. M. Wigley,Laura K. Hummers,J. Hummers,J. Lee Nelson,G. Riemekasten,Ariane L. Herrick,Lorenzo Beretta,Carmen Fonseca,Christopher P. Denton,Peter K. Gregersen,Sandeep K. Agarwal,Shervin Assassi,Filemon K. Tan,Frank C. Arnett,Timothy R D J Radstake,Maureen D. Mayes,Javier Martín +69 more
TL;DR: The aim of this study was to determine the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis (SSc), and to identify three new non-HLA genes associated with SSc clinical and auto-antibody subgroups.
Journal ArticleDOI
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci
Jose Ezequiel Martin,Shervin Assassi,Lina-Marcela Diaz-Gallo,Jasper C A Broen,Jasper C A Broen,Carmen P. Simeon,Ivan Castellví,Esther Vicente-Rabaneda,V. Fonollosa,Norberto Ortego-Centeno,Miguel A. González-Gay,Gerard Espinosa,Patricia Carreira,Mayte Camps,José Mario Sabio,Sandra D'Alfonso,Madelon C. Vonk,Alexandre E. Voskuyl,Annemie J. Schuerwegh,Alexander Kreuter,Torsten Witte,G. Riemekasten,Nicolas Hunzelmann,Paolo Airò,Lorenzo Beretta,Raffaella Scorza,Claudio Lunardi,Jacob M van Laar,Meng May Chee,Jane Worthington,Arianne Herrick,Christopher P. Denton,Carmen Fonseca,Filemon K. Tan,Frank C. Arnett,Xiaodong Zhou,John D. Reveille,Olga Y. Gorlova,Bobby P. C. Koeleman,Timothy R D J Radstake,Timothy J. Vyse,Maureen D. Mayes,Marta E. Alarcón-Riquelme,Javier Martín +43 more
TL;DR: A pan-meta-analysis of two genome-wide association studies together with a replication stage including additional SSc and SLE cohorts increased the sample size to a total of 21,109 and validated KIAA0319L, PXK and JAZF1 as novel susceptibility loci for SSc or SLE, increasing significantly the knowledge of the genetic basis of autoimmunity.
Journal ArticleDOI
Identification of CSK as a systemic sclerosis genetic risk factor through Genome Wide Association Study follow-up
Jose Ezequiel Martin,Jasper C A Broen,F. David Carmona,María Teruel,Carmen P. Simeon,Madelon C. Vonk,Ruben van 't Slot,Luis Rodriguez-Rodriguez,Esther F. Vicente,V. Fonollosa,Norberto Ortego-Centeno,Miguel A. González-Gay,Francisco J. García-Hernández,Paloma García de la Peña,Patricia Carreira,Alexandre E. Voskuyl,Annemie J. Schuerwegh,Piet L. C. M. van Riel,Alexander Kreuter,Torsten Witte,G. Riemekasten,Paolo Airò,Raffaella Scorza,Claudio Lunardi,Nicolas Hunzelmann,Jörg H W Distler,Lorenzo Beretta,Jacob M van Laar,Meng May Chee,Jane Worthington,Ariane L. Herrick,Christopher P. Denton,Filemon K. Tan,Frank C. Arnett,Shervin Assassi,Carmen Fonseca,Maureen D. Mayes,Timothy R D J Radstake,Bobby P. C. Koeleman,Javier Martín +39 more
TL;DR: This study significantly increases the number of known putative genetic risk factors for SSc, including the genes CSK, PSD3 and NFKB1, and further confirms six previously described ones.
Journal ArticleDOI
A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort
Lara Bossini-Castillo,Jasper C A Broen,Carmen P. Simeon,Lorenzo Beretta,Madelon C. Vonk,Norberto Ortego-Centeno,Gerard Espinosa,Patricia Carreira,María Teresa Camps,Nuria Navarrete,María Francisca González-Escribano,Esther Vicente-Rabaneda,Luis Rodriguez Rodriguez,C. Tolosa,José Andrés Román-Ivorra,Inmaculada Gómez-Gracia,Francisco J. García-Hernández,Ivan Castellví,María Cruz Gallego,Antonio Fernández-Nebro,Rosa Garcia-Portales,María Victoria Egurbide,V. Fonollosa,Paloma García de la Peña,Ana Pros,Miguel A. Gonzalez-Gay,Roger Hesselstrand,Gabriela Riemekasten,Torsten Witte,Marieke J H Coenen,Bobby P. C. Koeleman,Frédéric Houssiau,Vanessa Smith,Filip De Keyser,Rene Westhovens,Ellen De Langhe,Alexandre E. Voskuyl,Annemie J. Schuerwegh,Meng May Chee,Rajan Madhok,Paul G. Shiels,Carmen Fonseca,Christopher P. Denton,Kathleen Claes,Leonid Padykov,Annika Nordin,Øyvind Palm,Benedicte A. Lie,Paolo Airò,Raffaella Scorza,Jacob M van Laar,Nicolas Hunzelmann,Alexander Kreuter,Ariane L. Herrick,Jane Worthington,Timothy R D J Radstake,Javier Martin,Blanca Rueda +57 more
TL;DR: The data confirm the influence of TNFSF4 polymorphisms in SSc genetic susceptibility, especially in subsets of patients positive for lcSSc and ACA positive subgroups, and revealed a new risk haplotype associated with the same groups of patients.