Y
Younghun Han
Researcher at Baylor College of Medicine
Publications - 83
Citations - 4133
Younghun Han is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Lung cancer & Genome-wide association study. The author has an hindex of 27, co-authored 72 publications receiving 3352 citations. Previous affiliations of Younghun Han include Dartmouth College & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
James D. McKay,Rayjean J. Hung,Younghun Han,Xuchen Zong,Robert Carreras-Torres,David C. Christiani,Neil E. Caporaso,Mattias Johansson,Xiangjun Xiao,Yafang Li,Jinyoung Byun,Alison M. Dunning,Karen A. Pooley,David C. Qian,Xuemei Ji,Geoffrey Liu,Maria Timofeeva,Stig E. Bojesen,Stig E. Bojesen,Stig E. Bojesen,Xifeng Wu,Loic Le Marchand,Demetrios Albanes,Heike Bickeböller,Melinda C. Aldrich,William S. Bush,Adonina Tardón,Gad Rennert,M. Dawn Teare,John K. Field,Lambertus A. Kiemeney,Philip Lazarus,Aage Haugen,Stephen Lam,Matthew B. Schabath,Angeline S. Andrew,Hongbing Shen,Yun Chul Hong,Jian-Min Yuan,Pier Alberto Bertazzi,Angela Cecilia Pesatori,Yuanqing Ye,Nancy Diao,Li Su,Ruyang Zhang,Yonathan Brhane,Natasha B. Leighl,Jakob S Johansen,Anders Mellemgaard,Walid Saliba,Christopher A. Haiman,Lynne R. Wilkens,Ana Fernández-Somoano,Guillermo Fernández-Tardón,Henricus F. M. van der Heijden,Jin Hee Kim,Juncheng Dai,Zhibin Hu,Michael P.A. Davies,Michael W. Marcus,Hans Brunnström,Jonas Manjer,Olle Melander,David C. Muller,Kim Overvad,Antonia Trichopoulou,Rosario Tumino,Jennifer A. Doherty,Matt P Barnett,Chu Chen,Gary E. Goodman,Angela Cox,Fiona Taylor,Penella J. Woll,Irene Brüske,H-Erich Wichmann,H-Erich Wichmann,Judith Manz,Thomas Muley,Angela Risch,Albert Rosenberger,Kjell Grankvist,Mikael Johansson,Frances A. Shepherd,Ming-Sound Tsao,Susanne M. Arnold,Eric B. Haura,Ciprian Bolca,Ivana Holcatova,Vladimir Janout,Milica Kontic,Jolanta Lissowska,Anush Mukeria,Simona Ognjanovic,Tadeusz M Orlowski,Ghislaine Scelo,Beata Swiatkowska,David Zaridze,Per Bakke,Vidar Skaug,Shanbeh Zienolddiny,Eric J. Duell,Lesley M. Butler,Woon-Puay Koh,Yu-Tang Gao,Richard S. Houlston,John McLaughlin,Victoria L. Stevens,Philippe Joubert,Maxime Lamontagne,David C. Nickle,Ma'en Obeidat,Wim Timens,Bin Zhu,Lei Song,Linda Kachuri,María Soler Artigas,María Soler Artigas,Martin D. Tobin,Martin D. Tobin,Louise V. Wain,Louise V. Wain,Thorunn Rafnar,Thorgeir E. Thorgeirsson,Gunnar W Reginsson,Kari Stefansson,Dana B. Hancock,Laura J. Bierut,Margaret R. Spitz,Nathan C. Gaddis,Sharon M. Lutz,Fangyi Gu,Eric O. Johnson,Ahsan Kamal,Claudio W. Pikielny,Dakai Zhu,Sara Lindstroem,Xia Jiang,Rachel F. Tyndale,Rachel F. Tyndale,Georgia Chenevix-Trench,Jonathan Beesley,Yohan Bossé,Stephen J. Chanock,Paul Brennan,Maria Teresa Landi,Christopher I. Amos +146 more
TL;DR: 18 susceptibility loci achieving genome-wide significance are identified, including 10 new loci linked with lung cancer overall and six loci associated with lung adenocarcinoma, highlighting the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer.
Journal ArticleDOI
Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD
Nancy L. Saccone,Nancy L. Saccone,Robert Culverhouse,Tae-Hwi Schwantes-An,Dale S. Cannon,Xiangning Chen,Sven Cichon,Ina Giegling,Shizhong Han,Younghun Han,Kaisu Keskitalo-Vuokko,Xiangyang Kong,Maria Teresa Landi,Jennie Z. Ma,Susan E. Short,Susan E. Short,Sarah H. Stephens,Victoria L. Stevens,Lingwei Sun,Yufei Wang,Angela S. Wenzlaff,Steven H. Aggen,Naomi Breslau,Peter Broderick,Nilanjan Chatterjee,Jingchun Chen,Andrew C. Heath,Markku Heliövaara,Nicole R. Hoft,David J. Hunter,Majken K. Jensen,Nicholas G. Martin,Grant W. Montgomery,Tianhua Niu,Thomas J. Payne,Leena Peltonen,Michele L. Pergadia,John P. Rice,Richard Sherva,Margaret R. Spitz,Juzhong Sun,Jen C. Wang,Robert B. Weiss,William Wheeler,Stephanie H. Witt,Bao-Zhu Yang,Neil E. Caporaso,Marissa A. Ehringer,Tim Eisen,Susan M. Gapstur,Joel Gelernter,Richard S. Houlston,Jaakko Kaprio,Jaakko Kaprio,Kenneth S. Kendler,Peter Kraft,Mark Leppert,Ming D. Li,Pamela A. F. Madden,Markus M. Nöthen,Sreekumar G. Pillai,Marcella Rietschel,Dan Rujescu,Ann G. Schwartz,Christopher I. Amos,Laura J. Bierut +65 more
TL;DR: This study provides strong evidence that multiple statistically distinct loci in this region affect smoking behavior, and is the first report of association between rs588765 (and correlates) and smoking that achieves genome-wide significance.
Journal ArticleDOI
Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
Timothy R D J Radstake,Olga Y. Gorlova,Blanca Rueda,Jose Ezequiel Martin,Behrooz Z. Alizadeh,Rogelio Palomino-Morales,Marieke J H Coenen,Madelon C. Vonk,Alexandre E. Voskuyl,Annemie J. Schuerwegh,Jasper C A Broen,Piet L. C. M. van Riel,Ruben van 't Slot,Annet Italiaander,Roel A. Ophoff,Roel A. Ophoff,Gabriela Riemekasten,Nico Hunzelmann,Carmen P. Simeon,Norberto Ortego-Centeno,Miguel A. Gonzalez-Gay,María Francisca González-Escribano,Paolo Airò,Jaap M van Laar,Ariane L. Herrick,Jane Worthington,Roger Hesselstrand,Vanessa Smith,Filip De Keyser,Fredric Houssiau,Meng May Chee,Rajan Madhok,Paul G. Shiels,Rene Westhovens,Alexander Kreuter,Hans P. Kiener,Elfride De Baere,Torsten Witte,Leonid Padykov,Lars Klareskog,Lorenzo Beretta,Rafaella Scorza,Benedicte A. Lie,Anna Maria Hoffmann-Vold,Patricia Carreira,John Varga,Monique Hinchcliff,Peter K. Gregersen,Annette Lee,Jun Ying,Younghun Han,Shih-Feng Weng,Christopher I. Amos,Fredrick M. Wigley,Laura K. Hummers,J. Lee Nelson,Sandeep K. Agarwal,Shervin Assassi,Pravitt Gourh,Filemon K. Tan,Bobby P. C. Koeleman,Frank C. Arnett,Javier Martín,Maureen D. Mayes +63 more
TL;DR: The first genome-wide association study in a population of European ancestry including a total of 2,296 individuals with SSc and 5,171 controls identified a new susceptibility locus for systemic sclerosis at CD247 (1q22–23, rs2056626).
Journal ArticleDOI
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer
Yufei Wang,James McKay,Thorunn Rafnar,Zhaoming Wang,Maria Timofeeva,Peter Broderick,Xuchen Zong,Marina Laplana,Yongyue Wei,Younghun Han,Amy Lloyd,Manon Delahaye-Sourdeix,Daniel Chubb,Valerie Gaborieau,William Wheeler,Nilanjan Chatterjee,Gudmar Thorleifsson,Patrick Sulem,Geoffrey Liu,Rudolf Kaaks,Marc Henrion,Ben Kinnersley,Maxime Vallée,Florence LeCalvez-Kelm,Victoria L. Stevens,Susan M. Gapstur,Wei V. Chen,David Zaridze,Neonilia Szeszenia-Dabrowska,Jolanta Lissowska,Peter Rudnai,Eleonora Fabianova,Dana Mates,Vladimir Bencko,Lenka Foretova,Vladimir Janout,Hans E. Krokan,Maiken Elvestad Gabrielsen,Frank Skorpen,Lars J. Vatten,Inger Njølstad,Chu Chen,Gary E. Goodman,Simone Benhamou,Tõnu Vooder,Kristjan Välk,Mari Nelis,Andres Metspalu,Marcin Lener,Jan Lubinski,Mattias Johansson,Paolo Vineis,Antonio Agudo,Françoise Clavel-Chapelon,H. Bas Bueno-de-Mesquita,H. Bas Bueno-de-Mesquita,Dimitrios Trichopoulos,Dimitrios Trichopoulos,Kay-Tee Khaw,Mikael Johansson,Elisabete Weiderpass,Anne Tjønneland,Elio Riboli,Mark Lathrop,Ghislaine Scelo,Demetrius Albanes,Neil E. Caporaso,Yuanqing Ye,Jian Gu,Xifeng Wu,Margaret R. Spitz,Hendrik Dienemann,Albert Rosenberger,Li Su,Athena Matakidou,T. Eisen,Kari Stefansson,Angela Risch,Stephen J. Chanock,David C. Christiani,Rayjean J. Hung,Paul Brennan,Maria Teresa Landi,Richard S. Houlston,Christopher I. Amos +84 more
TL;DR: The analysis demonstrates that imputation can identify rare disease-causing variants with substantive effects on cancer risk from preexisting genome-wide association study data and provides further evidence for inherited genetic susceptibility to lung cancer and its biological basis.
Journal ArticleDOI
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
Heather J. Cordell,Younghun Han,George F. Mells,Yafang Li,Gideon M. Hirschfield,Casey S. Greene,Gang Xie,Brian D. Juran,Dakai Zhu,David C. Qian,James A B Floyd,James A B Floyd,Katherine I. Morley,Katherine I. Morley,Daniele Prati,Ana Lleo,Daniele Cusi,Daniele Cusi,M. Eric Gershwin,Carl A. Anderson,Konstantinos N. Lazaridis,Pietro Invernizzi,Michael F. Seldin,Richard Sandford,Christopher I. Amos,Katherine A. Siminovitch,Erik M. Schlicht,Craig Lammert,Elizabeth J. Atkinson,Landon L. Chan,Mariza de Andrade,Tobias Balschun,Andrew Mason,Robert P. Myers,Jinyi Zhang,Piotr Milkiewicz,Jia Qu,Joseph A. Odin,Velimir A. Luketic,Bruce R. Bacon,Henry C. Bodenheimer,Valentina Liakina,Catherine Vincent,Cynthia Levy,Peter K. Gregersen,Piero Luigi Almasio,Domenico Alvaro,Pietro Andreone,Angelo Andriulli,Cristina Barlassina,Pier Maria Battezzati,Antonio Benedetti,Francesca Bernuzzi,Ilaria Bianchi,Maria Consiglia Bragazzi,Maurizia Rossana Brunetto,Savino Bruno,Giovanni Casella,Barbara Coco,Agostino Colli,Massimo Colombo,Silvia Colombo,Carmela Cursaro,Lory Saveria Crocè,Andrea Crosignani,Maria Francesca Donato,Gianfranco Elia,Luca Fabris,Carlo Ferrari,Annarosa Floreani,Barbara Foglieni,R. Fontana,Andrea Galli,Roberta Lazzari,Fabio Salvatore Macaluso,Federica Malinverno,Fabio Marra,Marco Marzioni,Alberto Mattalia,Renzo Montanari,Lorenzo Morini,Filomena Morisco,S. Mousa Hani,Luigi Muratori,Paolo Muratori,Grazia Anna Niro,Vincenzo Palmieri,Antonio Picciotto,Mauro Podda,Piero Portincasa,Vincenzo Ronca,Floriano Rosina,Sonia Rossi,Ilaria Sogno,Giancarlo Spinzi,M. Spreafico,Mario Strazzabosco,Mario Strazzabosco,Sonia Tarallo,Mirko Tarocchi,Claudio Tiribelli,Pierluigi Toniutto,Maria Vinci,Massimo Zuin,Chin Lye Ch'ng,Mesbah Rahman,Tom Yapp,Richard Sturgess,Chris Healey,Marek Czajkowski,Anton V J Gunasekera,Pranab Gyawali,Purushothaman Premchand,Kapil Kapur,Richard Marley,Graham R. Foster,Alan Watson,Aruna Dias,Javaid Subhani,Rory Harvey,Roger McCorry,David Ramanaden,Jaber Gasem,Richard Evans,Thiriloganathan Mathialahan,Christopher Shorrock,George Lipscomb,Paul Southern,Jeremy Tibble,David Gorard,Altaf Palegwala,Susan Jones,Marco Carbone,Mohamed Dawwas,Graeme J.M. Alexander,Sunil Dolwani,Martin Prince,Matthew Foxton,David A Elphick,H.C. Mitchison,Ian Gooding,Mazn Karmo,Sushma Saksena,Mike Mendall,Minesh Patel,Roland Ede,Andrew Austin,Joanna Sayer,Lorraine Hankey,Christopher Hovell,N Fisher,M J Carter,M J Carter,Konrad Koss,Andrzej Piotrowicz,Charles Grimley,David E. Neal,Guan Lim,Sass Levi,Aftab Ala,Andrea Broad,Athar Saeed,Gordon Wood,Jonathan C Brown,Mark Wilkinson,Harriet Gordon,John Ramage,Jo Ridpath,Theodore Ngatchu,Bob Grover,Syed Shaukat,Ray Shidrawi,G. Abouda,Faiz Ali,Ian Rees,Imroz Salam,Mark Narain,Ashley Brown,Simon D. Taylor-Robinson,Simon Williams,Leonie Grellier,Paul R. Banim,Debasish Das,Andrew Chilton,Michael A. Heneghan,Howard Curtis,Markus Gess,Ian Drake,M. Aldersley,M. Aldersley,Mervyn H. Davies,Mervyn H. Davies,Rebecca Jones,Rebecca Jones,Alastair McNair,Raj Srirajaskanthan,Maxton Pitcher,Maxton Pitcher,Sambit Sen,George Bird,Adrian Barnardo,Paul Kitchen,Kevin Yoong,Oza Chirag,Nurani Sivaramakrishnan,George MacFaul,David Jones,Amir Shah,Chris D. Evans,Subrata Saha,Katharine Pollock,Peter Bramley,Ashis Mukhopadhya,Andrew G. Fraser,Peter R. Mills,Christopher Shallcross,Stewart Campbell,Andrew Bathgate,Alan Shepherd,John F. Dillon,Simon M. Rushbrook,Robert Przemioslo,Christopher Macdonald,Jane Metcalf,Udi Shmueli,Andrew Davis,Asifabbas Naqvi,Thomas Lee,Dyder Stephen,Dyder Stephen,Jane Collier,Howard Klass,Mary Ninkovic,Matthew E. Cramp,Nicholas Sharer,Richard Aspinall,Patrick Goggin,Deb Ghosh,Andrew C. Douds,Barbara Hoeroldt,Jonathan Booth,Earl J. Williams,Hyder Hussaini,William Stableforth,Reuben Ayres,Douglas Thorburn,Eileen Marshall,Andrew K. Burroughs,Steven Mann,Martin Lombard,Paul G. Richardson,Imran Patanwala,Julia Maltby,Matthew J Brookes,Ray Mathew,Samir Vyas,Saket Singhal,Dermot Gleeson,Sharat Misra,Jeff Butterworth,Keith George,Tim Harding,Andrew Douglass,Simon Panter,Jeremy Shearman,Gary Bray,Graham Butcher,Daniel M. Forton,John McLindon,M. L. Cowan,Gregory Whatley,Aditya Mandal,Hemant Gupta,Pradeep Sanghi,Sanjiv Jain,S.P. Pereira,Geeta Prasad,Gill Watts,Mark Wright,James Neuberger,Fiona H. Gordon,Esther Unitt,Allister Grant,Toby E. S. Delahooke,Andrew D. Higham,Alison M. Brind,Mark Cox,Subramaniam Ramakrishnan,Alistair King,Carole Collins,Simon Whalley,Andy Li,Jocelyn Fraser,Andrew Bell,Voi Shim Wong,Amit Singhal,Ian Gee,Yeng Ang,Rupert Ransford,James Gotto,Charles Millson,Jane Bowles,Caradog Thomas,Melanie Harrison,Roman Galaska,Jennie Kendall,Jessica Whiteman,Caroline Lawlor,Catherine Gray,Keith Elliott,Caroline Mulvaney-Jones,Lucie Hobson,Greta Van Duyvenvoorde,Alison Loftus,Katie Seward,Ruth Penn,Jane Maiden,Rose Damant,Janeane Hails,Rebecca Cloudsdale,Valeria Silvestre,Sue Glenn,Eleanor Dungca,Natalie Wheatley,Helen Doyle,Melanie Kent,Caroline Hamilton,Delyth Braim,Helen Wooldridge,Rachel Abrahams,Alison Paton,Nicola Lancaster,Andrew Gibbins,Karen Hogben,Phillipa Desousa,Phillipa Desousa,Florin Muscariu,Janine Musselwhite,Alexandra McKay,Laiting Tan,Carole Foale,Jacqueline Brighton,Kerry Flahive,Estelle Nambela,Paula Townshend,Christopher B. Ford,Sophie Holder,Caroline Palmer,James Featherstone,Mariam Nasseri,Joy Sadeghian,Bronwen Williams,Carol Thomas,Sally Ann Rolls,Abigail Hynes,Claire Duggan,Sarah Jones,Mary M.E. Crossey,Glynis Stansfield,Carolyn MacNicol,Joy Wilkins,Elva Wilhelmsen,Parizade Raymode,Hye Jeong Lee,Emma Durant,Rebecca Bishop,Rebecca Bishop,Noma Ncube,Sherill Tripoli,Sherill Tripoli,Rebecca Casey,Caroline Cowley,Richard A. Miller,Kathryn Houghton,Samantha Ducker,Fiona Wright,Bridget Bird,Gwen Baxter,Janie Keggans,Maggie Hughes,Emma Grieve,Karin Young,D. Williams,Kate Ocker,Frances Hines,Kirsty G. Martin,Caron Innes,Caron Innes,Talal Valliani,Helen Fairlamb,Sarah Thornthwaite,Anne Eastick,Elizabeth Tanqueray,Jennifer Morrison,Becky Holbrook,Julie Browning,Kirsten Walker,Susan Congreave,Susan Congreave,Juliette Verheyden,Juliette Verheyden,Susan Slininger,Susan Slininger,Lizzie Stafford,Denise O'Donnell,Mark A. Ainsworth,Susan Lord,Linda Kent,Linda March,Christine Dickson,Diane Simpson,Beverley Longhurst,Maria Hayes,Ervin Shpuza,Nikki White,Sarah Besley,Sallyanne Pearson,Alice Wright,L. Jones,Emma Gunter,H. Dewhurst,Anna Fouracres,Liz Farrington,Lyn Graves,Suzie Marriott,Marina Leoni,David Tyrer,Kate Martin,Lola Dali-Kemmery,Victoria Lambourne,Marie Green,Dawn Sirdefield,Kelly Amor,Julie Colley,Bal Shinder,Jayne Jones,Marisa Mills,Mandy Carnahan,Natalie Taylor,Kerenza Boulton,Julie Tregonning,Carly Brown,Gayle Clifford,Emily Archer,Maria Hamilton,Janette Curtis,Tracey Shewan,Susan Walsh,Karen Warner,Kimberley Netherton,McDonald Mupudzi,Bridget Gunson,Jane Gitahi,Denise Gocher,Sally Batham,Hilary Pateman,Senayon Desmennu,Jill Conder,Darren Clement,Susan Gallagher,Jacky Orpe,Puiching Chan,Lynn Currie,Lynn O'Donohoe,Metod Oblak,Lisa Morgan,Marie Quinn,Isobel Amey,Yolanda Baird,Donna Cotterill,Lourdes Cumlat,Louise Winter,Sandra Greer,Katie Spurdle,Joanna Allison,Simon Dyer,Helen Sweeting,Jean Kordula +477 more
TL;DR: This work discovers and validate six previously unknown risk loci for PBC and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine–cytokine pathways, for which relevant therapies exist.