M
Meredith E. Caldwell
Researcher at Cancer Research UK
Publications - 3
Citations - 3696
Meredith E. Caldwell is an academic researcher from Cancer Research UK. The author has contributed to research in topics: Pancreatic cancer & Drug delivery. The author has an hindex of 2, co-authored 3 publications receiving 3301 citations.
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Journal ArticleDOI
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive,Michael A. Jacobetz,Christian Davidson,Aarthi Gopinathan,Aarthi Gopinathan,Dominick J.O. McIntyre,Davina J. Honess,Basetti Madhu,Mae A. Goldgraben,Meredith E. Caldwell,David Allard,Kristopher K. Frese,Gina M. DeNicola,Gina M. DeNicola,Christine Feig,Chelsea Combs,Stephen P. Winter,Heather Ireland-Zecchini,Stefanie Reichelt,William J. Howat,Alex R. Chang,Mousumi Dhara,Lifu Wang,Lifu Wang,Felix Rückert,Robert Grützmann,Christian Pilarsky,Kamel Izeradjene,Sunil R. Hingorani,Pearl S. Huang,Susan E. Davies,William Plunkett,Merrill J. Egorin,Ralph H. Hruban,Nigel Whitebread,Karen McGovern,Julian Adams,Christine A. Iacobuzio-Donahue,John R. Griffiths,David A. Tuveson +39 more
TL;DR: Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, it is found that the tumors in this model were poorly perfused and poorly vascularized, properties that are shared with human PDA.
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Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
Michael A. Jacobetz,Derek S. Chan,Albrecht Neesse,Tashinga E. Bapiro,Natalie Cook,Kristopher K. Frese,Christine Feig,Tomoaki Nakagawa,Meredith E. Caldwell,Heather I Zecchini,Martijn P. Lolkema,Ping Jiang,Anne Kultti,Curtis B. Thompson,Daniel C. Maneval,Duncan I. Jodrell,Gregory I. Frost,Harold Michael Shepard,Jeremy N. Skepper,David A. Tuveson +19 more
TL;DR: It is demonstrated that HA impedes the intratumoral vasculature in PDA and proposed that its enzymatic depletion be explored as a means to improve drug delivery and response in patients with pancreatic cancer.
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