H
Heather Ireland-Zecchini
Researcher at University of Cambridge
Publications - 8
Citations - 3192
Heather Ireland-Zecchini is an academic researcher from University of Cambridge. The author has contributed to research in topics: In vivo & Bioorthogonal chemistry. The author has an hindex of 8, co-authored 8 publications receiving 2907 citations. Previous affiliations of Heather Ireland-Zecchini include Cancer Research UK.
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Journal ArticleDOI
Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive,Michael A. Jacobetz,Christian Davidson,Aarthi Gopinathan,Aarthi Gopinathan,Dominick J.O. McIntyre,Davina J. Honess,Basetti Madhu,Mae A. Goldgraben,Meredith E. Caldwell,David Allard,Kristopher K. Frese,Gina M. DeNicola,Gina M. DeNicola,Christine Feig,Chelsea Combs,Stephen P. Winter,Heather Ireland-Zecchini,Stefanie Reichelt,William J. Howat,Alex R. Chang,Mousumi Dhara,Lifu Wang,Lifu Wang,Felix Rückert,Robert Grützmann,Christian Pilarsky,Kamel Izeradjene,Sunil R. Hingorani,Pearl S. Huang,Susan E. Davies,William Plunkett,Merrill J. Egorin,Ralph H. Hruban,Nigel Whitebread,Karen McGovern,Julian Adams,Christine A. Iacobuzio-Donahue,John R. Griffiths,David A. Tuveson +39 more
TL;DR: Studying a mouse model of PDA that is refractory to the clinically used drug gemcitabine, it is found that the tumors in this model were poorly perfused and poorly vascularized, properties that are shared with human PDA.
Journal ArticleDOI
Development and evaluation of new cyclooctynes for cell surface glycan imaging in cancer cells.
Henning Stöckmann,André A. Neves,Shaun Stairs,Heather Ireland-Zecchini,Kevin M. Brindle,Finian J. Leeper +5 more
TL;DR: In this paper, two reagents have been synthesized for selective labeling of cell surface azidoglycans, an unusually stable version of a dibenzo cyclooctyne (TMDIBO) and a third-generation difluorinated cyclooCTyne (DIFO3).
Journal ArticleDOI
Imaging sialylated tumor cell glycans in vivo
André A. Neves,Henning Stöckmann,Rebecca Harmston,Helen J. Pryor,Israt S. Alam,Heather Ireland-Zecchini,David Y. Lewis,Scott K. Lyons,Finian J. Leeper,Kevin M. Brindle +9 more
TL;DR: The technique has the potential to translate to the clinic, where, given the prognostic relevance of altered sialic acid expression in cancer, it could be used to monitor disease progression, and for the first time, fluorescence and radionuclide imaging of sialylated glycans in a murine tumor model in vivo.
Journal ArticleDOI
Metabolic glycan imaging by isonitrile-tetrazine click chemistry.
Shaun Stairs,André A. Neves,Henning Stöckmann,Yéléna A. Wainman,Heather Ireland-Zecchini,Kevin M. Brindle,Finian J. Leeper +6 more
TL;DR: This bioorthogonal isonitrile-tetrazine ligation is also orthogonal to the commonly used azide-cyclooctyne ligation, and so will allow simultaneous detection of the incorporation of two different sugars.
Journal ArticleDOI
Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer
Vincent Zecchini,Basetti Madhu,Roslin Russell,Nelma Pértega-Gomes,Anne Y. Warren,Edoardo Gaude,Joana Borlido,Rory Stark,Heather Ireland-Zecchini,Roheet Bantval Rao,H Scott,Joan Boren,Charles E. Massie,Mohammad Asim,Kevin M. Brindle,John R. Griffiths,Christian Frezza,David E. Neal,Ian G. Mills +18 more
TL;DR: This study is the first example of an endocytic adaptor protein regulating metabolic pathways and implicates ARRB1 as a potential tumour promoter in prostate cancer and highlights the importance of metabolic alterations in prostate cancers.