Yolanda Cámara

TL;DR: The results thus show that TFB1M is a nonredundant dimethyltransferase in mammalian mitochondria and provide a possible explanation for the universal conservation of adenine dimethylation of rRNA by showing a critical role in ribosome maintenance.

TL;DR: It is shown here that the leucine‐rich pentatricopeptide repeat containing (LRPPRC) gene is essential for embryonic development and point to the existence of an elaborate machinery that regulates mammalian mtDNA expression at the post‐transcriptional level.

TL;DR: The results thus show that MTERF4 is an important regulator of translation in mammalian mitochondria and directly controls mitochondrial ribosomal biogenesis and translation.

TL;DR: It is shown that MTERF3 is a negative regulator of mtDNA transcription initiation, the first example of a mitochondrial protein that acts as a specific repressor of mammalian mt DNA transcription initiation in vivo.

TL;DR: It is reported that mitochondrial protein synthesis is unimpaired in mtDNA mutator mice consistent with the observed minor alterations of steady-state levels of mitochondrial transcripts, and these findings refute recent claims that circular mtDNA molecules with large deletions are driving the premature aging phenotype.