Y
Yonghong Shi
Researcher at University of Gothenburg
Publications - 31
Citations - 2191
Yonghong Shi is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 14, co-authored 16 publications receiving 1861 citations. Previous affiliations of Yonghong Shi include Karolinska Institutet & Max Planck Society.
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Journal ArticleDOI
Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome.
Metodi D. Metodiev,Nicole Lesko,Chan Bae Park,Yolanda Cámara,Yonghong Shi,Rolf Wibom,Kjell Hultenby,Claes M. Gustafsson,Nils-Göran Larsson +8 more
TL;DR: The results thus show that TFB1M is a nonredundant dimethyltransferase in mammalian mitochondria and provide a possible explanation for the universal conservation of adenine dimethylation of rRNA by showing a critical role in ribosome maintenance.
Journal ArticleDOI
MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome
Yolanda Cámara,Jorge Asin-Cayuela,Chan Bae Park,Metodi D. Metodiev,Yonghong Shi,Yonghong Shi,Benedetta Ruzzenente,Christian Kukat,Bianca Habermann,Rolf Wibom,Kjell Hultenby,Thomas Franz,Hediye Erdjument-Bromage,Paul Tempst,B. Martin Hallberg,Claes M. Gustafsson,Nils-Göran Larsson,Nils-Göran Larsson +17 more
TL;DR: The results thus show that MTERF4 is an important regulator of translation in mammalian mitochondria and directly controls mitochondrial ribosomal biogenesis and translation.
Journal ArticleDOI
MTERF3 Is a Negative Regulator of Mammalian mtDNA Transcription
Chan Bae Park,Jorge Asin-Cayuela,Yolanda Cámara,Yonghong Shi,Mina Pellegrini,Martina Gaspari,Rolf Wibom,Kjell Hultenby,Hediye Erdjument-Bromage,Paul Tempst,Maria Falkenberg,Claes M. Gustafsson,Nils-Göran Larsson +12 more
TL;DR: It is shown that MTERF3 is a negative regulator of mtDNA transcription initiation, the first example of a mitochondrial protein that acts as a specific repressor of mammalian mt DNA transcription initiation in vivo.
Journal ArticleDOI
Human Mitochondrial Transcription Revisited ONLY TFAM AND TFB2M ARE REQUIRED FOR TRANSCRIPTION OF THE MITOCHONDRIAL GENES IN VITRO
Dmitry Litonin,Marina Sologub,Yonghong Shi,Maria Savkina,Michael Anikin,Maria Falkenberg,Claes M. Gustafsson,Dmitry Temiakov +7 more
TL;DR: In this paper, the authors found that TFAM and TFB2M act synergistically and increase transcription efficiency 100-200fold as compared with RNA polymerase alone, and that only two essential initiation factors are required to drive transcription of the mitochondrial genome.
Journal ArticleDOI
Mitochondrial RNA Polymerase Is Needed for Activation of the Origin of Light-Strand DNA Replication
Javier Miralles Fusté,Sjoerd Wanrooij,Elisabeth Jemt,Caroline Granycome,Tricia J. Cluett,Yonghong Shi,Neli Atanassova,Ian J. Holt,Claes M. Gustafsson,Claes M. Gustafsson,Maria Falkenberg +10 more
TL;DR: It is demonstrated that the mitochondrial RNA polymerase (POLRMT) is the primase required for initiation of DNA synthesis from the light-strand origin of DNA replication (OriL).