M
Michael C. Lam
Researcher at University of Hong Kong
Publications - 7
Citations - 1861
Michael C. Lam is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Adiponectin & Adipokine. The author has an hindex of 7, co-authored 7 publications receiving 1779 citations.
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Journal ArticleDOI
Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes
Aimin Xu,Aimin Xu,Kok Weng Chan,Ruby L. C. Hoo,Yu Wang,Yu Wang,Kathryn C.B. Tan,Jialiang Zhang,Baoying Chen,Michael C. Lam,Cynthia A. Tse,Garth J. S. Cooper,Karen S.L. Lam +12 more
TL;DR: The selective inhibition of HMW adip onectin by testosterone might contribute to the sex dimorphism of adiponectin in terms of its oligomeric complex distribution and could partly explain why men have higher risk to insulin resistance and atherosclerosis than women.
Journal ArticleDOI
Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation.
Kathryn C.B. Tan,Aimin Xu,Wing Sun Chow,Michael C. Lam,Victor H. G. Ai,Sidney Tam,Karen S.L. Lam +6 more
TL;DR: Low plasma adiponectin level is associated with impaired endothelium-dependent vasodilation, and the association is independent of diabetes mellitus.
Journal ArticleDOI
Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice.
Aimin Xu,Michael C. Lam,Kok Weng Chan,Yu Wang,Jialiang Zhang,Ruby L. C. Hoo,J. Y. Xu,Baoying Chen,Wing Sun Chow,Annette W.K. Tso,Karen S.L. Lam +10 more
TL;DR: Evidence is provided that ANGPTL4 is a blood-borne hormone directly involved in regulating glucoseHomeostasis, lipid metabolism, and insulin sensitivity, and that its beneficial effect on glucose homeostasis might be useful for the treatment of diabetes.
Journal ArticleDOI
Adiponectin modulates the glycogen synthase kinase-3β/β-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice
Yu Wang,Janice B Lam,Janice B Lam,Karen S.L. Lam,Jing Liu,Michael C. Lam,Ruby L. C. Hoo,Donghai Wu,Garth J. S. Cooper,Aimin Xu +9 more
TL;DR: The results showed that adiponectin significantly attenuated the proliferations of two typical human breast cancer cells, MDA-MB-231 and T47D, in a cell type-specific manner, and suggested that adip onectin might represent a novel therapeutic target for this disease.
Journal ArticleDOI
Post-translational Modifications of the Four Conserved Lysine Residues within the Collagenous Domain of Adiponectin Are Required for the Formation of Its High Molecular Weight Oligomeric Complex
Yu Wang,Yu Wang,Karen S.L. Lam,Lawrence Chan,Kok Weng Chan,Janice B. B. Lam,Michael C. Lam,Ruby C.L. Hoo,William Mak,Garth J. S. Cooper,Aimin Xu +10 more
TL;DR: Hydroxylation and glycosylation of the lysine residues within the collagenous domain of adiponectin are critically involved in regulating the formation of its HMW oligomeric complex and consequently contribute to the insulin-sensitizing activity of adip onectin in hepatocytes.