Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes
Aimin Xu,Aimin Xu,Kok Weng Chan,Ruby L. C. Hoo,Yu Wang,Yu Wang,Kathryn C.B. Tan,Jialiang Zhang,Baoying Chen,Michael C. Lam,Cynthia A. Tse,Garth J. S. Cooper,Karen S.L. Lam +12 more
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TLDR
The selective inhibition of HMW adip onectin by testosterone might contribute to the sex dimorphism of adiponectin in terms of its oligomeric complex distribution and could partly explain why men have higher risk to insulin resistance and atherosclerosis than women.About:
This article is published in Journal of Biological Chemistry.The article was published on 2005-05-06 and is currently open access. It has received 414 citations till now. The article focuses on the topics: Adiponectin.read more
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Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
TL;DR: The pathophysiology of adiponectin and adiponECTin receptors in insulin resistance, diabetes, and the metabolic syndrome is described and potential versatile therapeutic targets to combat obesity-linked diseases characterized by insulin resistance are described.
Journal ArticleDOI
Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications
TL;DR: In this paper, the authors summarized the state of the science since the last review in the Endocrine Reviews in 1997, and concluded that obese women with PCOS are insulin resistant, but some groups of lean affected women may have normal insulin sensitivity.
Journal ArticleDOI
Inactivation of the Fto gene protects from obesity
Julia Fischer,Linda Koch,Linda Koch,Christian Emmerling,Jeanette Vierkotten,Jeanette Vierkotten,Thomas Peters,Thomas Peters,Jens C. Brüning,Jens C. Brüning,Ulrich Rüther +10 more
TL;DR: These experiments provide the first direct demonstration that Fto is functionally involved in energy homeostasis by the control of energy expenditure, and leads to postnatal growth retardation and a significant reduction in adipose tissue and lean body mass.
Journal ArticleDOI
Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans
Xinmei Zhang,Dennis C.Y. Yeung,Michal Karpisek,David Stejskal,Zhiguang Zhou,Feng Liu,Rachel L.C. Wong,Wing Sun Chow,Annette W.K. Tso,Karen S.L. Lam,Aimin Xu +10 more
TL;DR: FGF21 is a novel adipokine associated with obesity-related metabolic complications in humans and the paradoxical increase of serum FGF21 in obese individuals, which may be explained by a compensatory response or resistance to FGF 21, warrants further investigation.
Journal ArticleDOI
Adipose Tissue-Derived Factors: Impact on Health and Disease
TL;DR: The endocrine functions of the adipose organ are widely studied at this stage and the systemic impact of adipocyte-derived factors on energy homeostasis is discussed.
References
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Journal ArticleDOI
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
Yukio Arita,Shinji Kihara,Noriyuki Ouchi,Masahiko Takahashi,Kazuhisa Maeda,Jun-ichiro Miyagawa,Kikuko Hotta,Iichiro Shimomura,Tadashi Nakamura,Koji Miyaoka,Hiroshi Kuriyama,Makoto Nishida,Shizuya Yamashita,Kosaku Okubo,Kenji Matsubara,Masahiro Muraguchi,Yasuichi Ohmoto,Tohru Funahashi,Yuji Matsuzawa +18 more
TL;DR: Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adip onectin is secreted only from adipose tissue.
Journal ArticleDOI
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
Toshimasa Yamauchi,Junji Kamon,Hironori Waki,Yasuo Terauchi,Naoto Kubota,Kazuo Hara,Y. Mori,Tomohiro Ide,Kouji Murakami,Nobuyo Tsuboyama-Kasaoka,Osamu Ezaki,Y. Akanuma,Oksana Gavrilova,Charles Vinson,Marc L. Reitman,Hiroyuki Kagechika,Koichi Shudo,Madoka Yoda,Yasuko Nakano,Kazuyuki Tobe,R. Nagai,Shigeko Kimura,Motowo Tomita,Philippe Froguel,Takashi Kadowaki +24 more
TL;DR: It is concluded that decreased adiponectin is implicated in the development of insulin resistance in mouse models of both obesity and lipoatrophy and that the replenishment of adiponECTin might provide a novel treatment modality for insulin resistance and type 2 diabetes.
Journal ArticleDOI
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
TL;DR: A novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte differentiation is described.
Journal ArticleDOI
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
TL;DR: It is proposed that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism, which triggers a transient decrease in basal glucose levels in mice treated with streptozotocin.
Journal ArticleDOI
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30.
Norikazu Maeda,Iichiro Shimomura,Ken Kishida,Hitoshi Nishizawa,Morihiro Matsuda,Hiroyuki Nagaretani,Naoki Furuyama,Hidehiko Kondo,Masahiko Takahashi,Yukio Arita,Ryutaro Komuro,Noriyuki Ouchi,Shinji Kihara,Yoshihiro Tochino,Keiichi Okutomi,Masato Horie,Satoshi Takeda,Toshifumi Aoyama,Tohru Funahashi,Yuji Matsuzawa +19 more
TL;DR: The results indicate that adiponectin/ACRP30 deficiency and high TNF-α levels in KO mice reduced muscle FATP-1 mRNA and IRS-1-mediated insulin signaling, resulting in severe diet-induced insulin resistance.
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