M
Michael D. Radmacher
Researcher at Ohio State University
Publications - 77
Citations - 13454
Michael D. Radmacher is an academic researcher from Ohio State University. The author has contributed to research in topics: Leukemia & BAALC. The author has an hindex of 40, co-authored 77 publications receiving 12921 citations. Previous affiliations of Michael D. Radmacher include Duke University & Kenyon College.
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Journal ArticleDOI
High expression of IGFBP2 is associated with chemoresistance in adult acute myeloid leukemia.
Andrea Kühnl,Martin Kaiser,Martin Neumann,Lars Fransecky,Sandra Heesch,Michael D. Radmacher,Guido Marcucci,Clara D. Bloomfield,Wolf-Karsten Hofmann,Eckhard Thiel,Claudia D. Baldus +10 more
TL;DR: A role of IGFBP2 and IGF signaling in chemoresistance of AML is suggested and patients with high IGF BP2 expression might benefit from molecular therapies targeting the IGF pathway.
Journal ArticleDOI
Chromosome abnormalities in malignant melanoma: clinical significance of nonrandom chromosome abnormalities in 206 cases.
Mark A. Nelson,Michael D. Radmacher,Richard Simon,Mikel Aickin,Jin Ming Yang,Lita Panda,Julia Emerson,Denise J. Roe,Lawrence Adair,FH Thompson,Jerry L. Bangert,Stanley P. L. Leong,Raymond Taetle,Sydney E. Salmon,Jeffrey M. Trent +14 more
TL;DR: It is suggested that recurring, nonrandom chromosome alterations play a key role in the etiology and/or progression of malignant melanoma and identify targets within the genome for molecular genetic studies.
Journal ArticleDOI
MicroRNA expression profiling in acute myeloid and chronic lymphocytic leukaemias.
TL;DR: Results of current studies analysing changes of microRNA expression in acute myeloid leukaemia and chronic lymphocytic leukaemias are reviewed, and their potential biologic, diagnostic and prognostic relevance are discussed.
Journal ArticleDOI
Gene Expression Profiling Reveals Similarities between the In vitro and In vivo Responses of Immune Effector Cells to IFN-α
Jason M. Zimmerer,Gregory B. Lesinski,Amy S. Ruppert,Michael D. Radmacher,Carl W. Noble,Kari Kendra,Michael Walker,William E. Carson +7 more
TL;DR: The transcriptional response of T cells, natural killer cells, and monocytes to IFN-α is described and microarray analysis of patient PBMCs after in vitro stimulation with IFn-α may be a useful predictor of the in vivo response of immune cells to IFM-α immunotherapy.
Molecular classification of cutaneous malignant melanoma by gene expression profiling
M. Bittner,P. Meltzer,Yi Chen,Yong-hui Jiang,E. A. Seftor,Mary J.C. Hendrix,Michael D. Radmacher,Richard M. Simon,Zohar Yakhini,Amir Ben-Dor,Nick Sampas,Edward R. Dougherty,E. Wang,Francesco M. Marincola,C. Gooden,John Lueders,Arthur A. Glatfelter,Pamela M. Pollock,John D. Carpten,E. Gillanders,D. Leja,K. Dietrich,Christian Beaudry,Michael E. Berens,David S. Alberts,Vernon K. Sondak +25 more
TL;DR: In this paper, a subset of melanomas identified by mathematical analysis of gene expression in a series of samples was identified by identifying the genes underlying the classification of this subset are differentially regulated in invasive melanomas.