Journal ArticleDOI
MicroRNA expression profiling in acute myeloid and chronic lymphocytic leukaemias.
TLDR
Results of current studies analysing changes of microRNA expression in acute myeloid leukaemia and chronic lymphocytic leukaemias are reviewed, and their potential biologic, diagnostic and prognostic relevance are discussed.About:
This article is published in Best Practice & Research Clinical Haematology.The article was published on 2009-06-01. It has received 33 citations till now. The article focuses on the topics: microRNA & Gene silencing.read more
Citations
More filters
Journal ArticleDOI
IDH1 and IDH2 Gene Mutations Identify Novel Molecular Subsets Within De Novo Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study
Guido Marcucci,Kati Maharry,Yue-Zhong Wu,Michael D. Radmacher,Krzysztof Mrózek,Dean Margeson,Kelsi B. Holland,Susan P. Whitman,Heiko Becker,Sebastian Schwind,Klaus H. Metzeler,Bayard L. Powell,Thomas H. Carter,Jonathan E. Kolitz,Meir Wetzler,Andrew J. Carroll,Maria R. Baer,Michael A. Caligiuri,Richard A. Larson,Clara D. Bloomfield +19 more
TL;DR: The R172 IDH2 mutations, previously unreported in AML, characterize a novel subset of CN-AML patients lacking other prognostic mutations and associate with unique gene- and microRNA-expression profiles that may lead to the discovery of novel, therapeutically targetable leukemogenic mechanisms.
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: In this article, a review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
Journal ArticleDOI
The prognostic and functional role of microRNAs in acute myeloid leukemia
TL;DR: It is reasonable to predict the development of novel microRNA-based therapeutic approaches in AML, and it has been demonstrated experimentally that antileukemic effects can be achieved by modulating microRNA expression by pharmacologic agents and/or increasing low endogenous levels of microRNAs with tumor suppressor function by synthetic microRNA oligonucleotides.
Journal ArticleDOI
The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis
Sadegh Babashah,Masoud Soleimani +1 more
TL;DR: It seems that the dysregulation of miRNAs involved in apoptosis may provide a mechanism for cancer development, and manipulating miRNA expression level may be a potential therapeutic strategy for curing cancer.
Journal ArticleDOI
Prognostic Significance of Expression of a Single MicroRNA, miR-181a, in Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study
Sebastian Schwind,Kati Maharry,Michael D. Radmacher,Krzysztof Mrózek,Kelsi B. Holland,Dean Margeson,Susan P. Whitman,Christopher Hickey,Heiko Becker,Klaus H. Metzeler,Peter Paschka,Claudia D. Baldus,Shujun Liu,Ramiro Garzon,Bayard L. Powell,Jonathan E. Kolitz,Andrew J. Carroll,Michael A. Caligiuri,Richard A. Larson,Guido Marcucci,Clara D. Bloomfield +20 more
TL;DR: To the knowledge, this work provides the first evidence that the expression of a single microRNA, miR-181a, is associated with clinical outcome of patients with CN-AML and may refine their molecular risk classification.
References
More filters
Journal ArticleDOI
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Journal ArticleDOI
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: The current understanding of miRNA target recognition in animals is outlined and the widespread impact of miRNAs on both the expression and evolution of protein-coding genes is discussed.
Journal ArticleDOI
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring.
Todd R. Golub,Todd R. Golub,Donna K. Slonim,Pablo Tamayo,Christine Huard,Michelle Gaasenbeek,Jill P. Mesirov,Hilary A. Coller,Mignon L. Loh,James R. Downing,Michael A. Caligiuri,Clara D. Bloomfield,Eric S. Lander +12 more
TL;DR: A generic approach to cancer classification based on gene expression monitoring by DNA microarrays is described and applied to human acute leukemias as a test case and suggests a general strategy for discovering and predicting cancer classes for other types of cancer, independent of previous biological knowledge.
Journal ArticleDOI
The functions of animal microRNAs
TL;DR: Evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.
Journal Article
MicroRNA signatures in human cancers
George A. Calin,Carlo M. Croce +1 more
TL;DR: The causes of the widespread differential expression of miRNA genes in malignant compared with normal cells can be explained by the location of these genes in cancer-associated genomic regions, by epigenetic mechanisms and by alterations in the miRNA processing machinery as discussed by the authors.
Related Papers (5)
miR-15 and miR-16 induce apoptosis by targeting BCL2.
MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia
Ramiro Garzon,Stefano Volinia,Stefano Volinia,Chang Gong Liu,Cecilia Fernandez-Cymering,Tiziana Palumbo,Flavia Pichiorri,Muller Fabbri,Kevin R. Coombes,Hansjuerg Alder,Tatsuya Nakamura,Neal Flomenberg,Guido Marcucci,George A. Calin,Steven M. Kornblau,Hagop M. Kantarjian,Clara D. Bloomfield,Michael Andreeff,Carlo M. Croce +18 more
Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin
Ramiro Garzon,Michela Garofalo,Maria Paola Martelli,Roger Briesewitz,Lisheng Wang,Cecilia Fernandez-Cymering,Stefano Volinia,Chang Gong Liu,Susanne Schnittger,Torsten Haferlach,Arcangelo Liso,Daniela Diverio,Marco Mancini,Giovanna Meloni,Robin Foà,Massimo F. Martelli,Cristina Mecucci,Carlo M. Croce,Brunangelo Falini +18 more
Distinct microRNA expression profiles in acute myeloid leukemia with common translocations
Zejuan Li,Jun Lu,Jun Lu,Miao Sun,Shuangli Mi,Hao Zhang,Roger T. Luo,Ping Chen,Yungui Wang,Ming Yan,Zhijian Qian,Mary Beth Neilly,Jie Jin,Yanming Zhang,Stefan K. Bohlander,Dong-Er Zhang,Richard A. Larson,Michelle M. Le Beau,Michael J. Thirman,Todd R. Golub,Todd R. Golub,Todd R. Golub,Janet D. Rowley,Jianjun Chen +23 more
MicroRNA expression in cytogenetically normal acute myeloid leukemia
Guido Marcucci,Michael D. Radmacher,Michael D. Radmacher,Kati Maharry,Kati Maharry,Krzysztof Mrózek,Amy S. Ruppert,Amy S. Ruppert,Peter Paschka,Tamara Vukosavljevic,Susan P. Whitman,Claudia D. Baldus,Christian Langer,Chang Gong Liu,Andrew J. Carroll,Bayard L. Powell,Ramiro Garzon,Carlo M. Croce,Jonathan E. Kolitz,Michael A. Caligiuri,Richard A. Larson,Clara D. Bloomfield +21 more