M
Michael E. Kurczy
Researcher at Scripps Research Institute
Publications - 40
Citations - 1862
Michael E. Kurczy is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Vesicle & Secondary ion mass spectrometry. The author has an hindex of 23, co-authored 36 publications receiving 1574 citations. Previous affiliations of Michael E. Kurczy include Chalmers University of Technology & University of Gothenburg.
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Journal ArticleDOI
Interactive XCMS Online: simplifying advanced metabolomic data processing and subsequent statistical analyses.
Harsha Gowda,Julijana Ivanisevic,Caroline H. Johnson,Michael E. Kurczy,H. Paul Benton,Duane Rinehart,Thomas Nguyen,Jayashree Ray,Jennifer V. Kuehl,Bernardo Arevalo,Peter D. Westenskow,Junhua Wang,Adam P. Arkin,Adam M. Deutschbauer,Gary J. Patti,Gary Siuzdak +15 more
TL;DR: An enhanced XCMS Online interface is introduced that enables users to perform dependent (paired) two-group comparisons, meta-analysis, and multigroup comparisons, with comprehensive statistical output and interactive visualization tools.
Journal ArticleDOI
Autonomous Metabolomics for Rapid Metabolite Identification in Global Profiling
H. Paul Benton,Julijana Ivanisevic,Nathaniel G. Mahieu,Michael E. Kurczy,Caroline H. Johnson,Lauren Franco,Duane Rinehart,Elizabeth R Valentine,Harsha Gowda,Baljit K. Ubhi,Ralf Tautenhahn,Andrew Gieschen,Matthew W. Fields,Gary J. Patti,Gary Siuzdak +14 more
TL;DR: The autonomous approach to untargeted metabolomics provides an efficient means of metabolomic profiling, and will ultimately allow the more rapid integration of comparative analyses, metabolite identification, and data analysis at a systems biology level.
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Thermal Degradation of Small Molecules: A Global Metabolomic Investigation
Mingliang Fang,Julijana Ivanisevic,H. Paul Benton,Caroline H. Johnson,Gary J. Patti,Linh Hoang,Winnie Uritboonthai,Michael E. Kurczy,Gary Siuzdak +8 more
TL;DR: Overall these analyses show that small molecules and metabolites undergo significant time-sensitive alterations when exposed to elevated temperatures, especially those conditions that mimic sample preparation and analysis in GC/MS experiments.
Journal ArticleDOI
Secondary Ion MS Imaging To Relatively Quantify Cholesterol in the Membranes of Individual Cells from Differentially Treated Populations
TL;DR: Relative, quantitative TOF-SIMS imaging has been used here to compare macrophage cells treated to contain elevated levels of cholesterol with respect to control cells and it should be possible to apply this procedure to the study of other selected lipids.
Journal ArticleDOI
Mass spectrometry imaging of mating Tetrahymena show that changes in cell morphology regulate lipid domain formation
Michael E. Kurczy,Michael E. Kurczy,Paul D. Piehowski,Craig T. Van Bell,Michael L. Heien,Nicolas Winograd,Andrew G. Ewing,Andrew G. Ewing +7 more
TL;DR: Time-of-flight secondary ion mass spectrometry images of mating Tetrahymena thermophila acquired at various stages during mating demonstrate that lipid domain formation, identified as a decrease in the lamellar lipid phosphatidylcholine, follows rather than precedes structural changes in the membrane.