M
Michael F. Mesleh
Researcher at Broad Institute
Publications - 37
Citations - 2795
Michael F. Mesleh is an academic researcher from Broad Institute. The author has contributed to research in topics: Residual dipolar coupling & Nuclear magnetic resonance spectroscopy. The author has an hindex of 21, co-authored 36 publications receiving 2546 citations. Previous affiliations of Michael F. Mesleh include Cubist Pharmaceuticals & University of Maryland Biotechnology Institute.
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Journal ArticleDOI
Structural Information from Ion Mobility Measurements: Effects of the Long-Range Potential
Michael F. Mesleh,Joanna M. Hunter,Alexandre A. Shvartsburg,and G. C. Schatz,Martin F. Jarrold +4 more
TL;DR: In this article, the authors compared mobilities calculated using the hard sphere projection approximation for a range of fullerenes (C20−C240) to those determined from trajectory calculations with a more realistic He−fullerene potential.
Journal ArticleDOI
Three-dimensional Structure of the Channel-forming Trans-membrane Domain of Virus Protein “u” (Vpu) from HIV-1
Sang Ho Park,Anthony A. Mrse,Alexander A. Nevzorov,Michael F. Mesleh,M. Oblatt-Montal,Mauricio Montal,Stanley J. Opella +6 more
TL;DR: The three-dimensional structure of the channel-forming trans-membrane domain of virus protein "u" (Vpu) of HIV-1 was determined by NMR spectroscopy in micelle and bilayer samples to determine the structural features of the ion-channel activity that may be associated with the protein's role in facilitating the budding of new virus particles from infected cells.
Journal ArticleDOI
Structure determination of membrane proteins by NMR spectroscopy
TL;DR: One- dimensional dipolar waves are an extension of two-dimensional PISA (polarity index slant angle) wheels that map pro- tein structures in NMR spectra of both weakly and completely aligned samples, and represent a convergence of solid-state and solution NMR approaches to structure determination.
Journal ArticleDOI
A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9.
Basudeb Maji,Basudeb Maji,Basudeb Maji,Soumyashree A. Gangopadhyay,Soumyashree A. Gangopadhyay,Soumyashree A. Gangopadhyay,Miseon Lee,Miseon Lee,Mengchao Shi,Mengchao Shi,Mengchao Shi,Peng Wu,Peng Wu,Peng Wu,Robert Heler,Beverly Mok,Beverly Mok,Donghyun Lim,Donghyun Lim,Sachini U. Siriwardena,Bishwajit Paul,Bishwajit Paul,Bishwajit Paul,Vlado Dančík,Amedeo Vetere,Michael F. Mesleh,Luciano A. Marraffini,Luciano A. Marraffini,David R. Liu,David R. Liu,David R. Liu,Paul A. Clemons,Bridget K. Wagner,Amit Choudhary,Amit Choudhary,Amit Choudhary +35 more
TL;DR: A generalizable platform is reported that provided the first synthetic small-molecule inhibitors of Streptococcus pyogenes Cas9 (SpCas9) that weigh <500 Da and are cell permeable, reversible, and stable under physiological conditions.
Journal ArticleDOI
Structural Information from Ion Mobility Measurements: Effects of the Long-Range Potential
Michael F. Mesleh,Joanna M. Hunter,Alexandre A. Shvartsburg,George C. Schatz,Martin F. Jarrold +4 more
TL;DR: In this paper, the authors compared mobilities calculated using the hard sphere projection approximation for a range of fullerenes (C20-C240) to those determined from trajectory calculations with a more realistic He -fullerene potential.