Michael Haber

TL;DR: It is shown that astrocytes in the hippocampal CA1 region detect synaptic activity induced by single-synaptic stimulation and increase basal synaptic transmission, finding an essential role in the regulation of elementary synaptic communication and providing insight into fundamental aspects of brain function.

TL;DR: This work presents a system that can be used to characterize the intricate relationship between astrocytic processes and synaptic structures in situ using organotypic hippocampal slices, a preparation that retains the three-dimensional architecture ofAstrocyte–synapse interactions.

TL;DR: DCC activation of Src is required for NMDAR-dependent LTP and certain forms of learning and memory and it is demonstrated that enhancing NMD AR function or activating Src rescues LTP in the absence of DCC.

TL;DR: It is demonstrated that ephrin stimulation of EphA4 leads to the recruitment and activation of phospholipase Cγ1 (PLCγ1) in heterologous cells and in hippocampal slices and modulate the association of the actin depolymerizing/severing factor cofilin with the plasma membrane.

TL;DR: It is shown that recombinant secretory leukocyte protease inhibitor injected intraperitoneally localizes to the nucleus of circulating leukocytes, is detected in the injured spinal cord, reduces activation of nuclear factor-kappaB and expression of tumour necrosis factor-alpha, and might be useful for the treatment of acute spinal cord injury.