E
Emilia Falkowska
Researcher at Scripps Research Institute
Publications - 9
Citations - 2483
Emilia Falkowska is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Epitope & Neutralization. The author has an hindex of 7, co-authored 9 publications receiving 2273 citations. Previous affiliations of Emilia Falkowska include International AIDS Vaccine Initiative & Ragon Institute of MGH, MIT and Harvard.
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Journal ArticleDOI
Broad neutralization coverage of HIV by multiple highly potent antibodies
Laura M. Walker,Michael Huber,Michael Huber,Katie J. Doores,Katie J. Doores,Emilia Falkowska,Emilia Falkowska,Robert Pejchal,Jean-Philippe Julien,Sheng-Kai Wang,Alejandra Ramos,Po-Ying Chan-Hui,Matthew Moyle,Jennifer L. Mitcham,Phillip W. Hammond,Ole A. Olsen,Pham Phung,Steven P. Fling,Chi-Huey Wong,Sanjay Phogat,Terri Wrin,Melissa Simek,Protocol G. Principal Investigators,Wayne C. Koff,Ian A. Wilson,Dennis R. Burton,Dennis R. Burton,Pascal Poignard,Pascal Poignard +28 more
TL;DR: Analysis of neutralization by the full complement of anti-HIV broadly neutralizing monoclonal antibodies now available reveals that certain combinations of antibodies should offer markedly more favourable coverage of the enormous diversity of global circulating viruses than others and these combinations might be sought in active or passive immunization regimes.
Journal ArticleDOI
Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers
Emilia Falkowska,Khoa Le,Khoa Le,Alejandra Ramos,Alejandra Ramos,Katie J. Doores,Katie J. Doores,Katie J. Doores,Jeong Hyun Lee,Jeong Hyun Lee,Claudia Blattner,Claudia Blattner,Alejandro Ramirez,Ronald Derking,Marit J. van Gils,Chi-Hui Liang,Chi-Hui Liang,Ryan McBride,Benjamin von Bredow,Sachin S. Shivatare,Chung-Yi Wu,Po-Ying Chan-Hui,Yan Liu,Ten Feizi,Michael B. Zwick,Wayne C. Koff,Michael S. Seaman,Kristine M. Swiderek,John P. Moore,David T. Evans,James C. Paulson,Chi-Huey Wong,Andrew B. Ward,Andrew B. Ward,Ian A. Wilson,Rogier W. Sanders,Pascal Poignard,Pascal Poignard,Dennis R. Burton +38 more
TL;DR: The availability of this set of antibodies expands the number of vaccine targets on HIV and provides reagents to characterize the native envelope spike, an important property given increasing evidence that cleavage is required for vaccine candidates that seek to mimic the functional HIV envelope spike.
Journal ArticleDOI
Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers.
Claudia Blattner,Jeong Hyun Lee,Kwinten Sliepen,Ronald Derking,Emilia Falkowska,Alba Torrents de la Peña,Albert Cupo,Jean-Philippe Julien,Marit J. van Gils,Peter Lee,Wenjie Peng,James C. Paulson,Pascal Poignard,Dennis R. Burton,John P. Moore,Rogier W. Sanders,Rogier W. Sanders,Ian A. Wilson,Andrew B. Ward +18 more
TL;DR: This work defines and structurally characterize a unique epitope on Env that is recognized by a recently discovered family of human monoclonal antibodies (PGT151-PGT158), and compares the structural and functional properties of membrane-extracted Env trimers from several clades with those of the soluble, cleaved SOSIP gp140 trimer.
Journal ArticleDOI
PGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4.
Emilia Falkowska,Alejandra Ramos,Yu Feng,Tongqing Zhou,Stephanie Moquin,Laura M. Walker,Xueling Wu,Michael S. Seaman,Terri Wrin,Peter D. Kwong,Richard T. Wyatt,John R. Mascola,Pascal Poignard,Dennis R. Burton,Dennis R. Burton +14 more
TL;DR: PGV04 is characterized, a MAb with potency and breadth that rivals those of the prototypic VRC01 and 3BNC117 and that mimicry of CD4, as assessed by inducing conformational changes in monomeric gp120 that lead to enhanced exposure of the CD4i site, is not uniquely correlated with effective neutralization at the site ofCD4 binding on HIV-1.
Journal ArticleDOI
Incomplete Neutralization and Deviation from Sigmoidal Neutralization Curves for HIV Broadly Neutralizing Monoclonal Antibodies
Laura E. McCoy,Emilia Falkowska,Emilia Falkowska,Katherine Doores,Khoa Le,Devin Sok,Marit J. van Gils,Zelda Euler,Judith A. Burger,Michael S. Seaman,Rogier W. Sanders,Hanneke Schuitemaker,Pascal Poignard,Terri Wrin,Dennis R. Burton,Dennis R. Burton +15 more
TL;DR: In conclusion, incomplete neutralization and non-sigmoidal neutralization curves are possible for all HIV bnMAbs against a wide range of viruses produced and assayed in both cell lines and primary cells with implications for the use of antibodies in therapy and as tools for vaccine design.