M
Michael Letko
Researcher at National Institutes of Health
Publications - 28
Citations - 3602
Michael Letko is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Coronavirus & Medicine. The author has an hindex of 14, co-authored 23 publications receiving 2532 citations. Previous affiliations of Michael Letko include Icahn School of Medicine at Mount Sinai & Skidmore College.
Papers
More filters
Journal ArticleDOI
Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses.
TL;DR: An approach to rapidly screen lineage B betacoronaviruses, such as SARS-CoV and the recently emerged SARS -CoV-2, for receptor usage and their ability to infect cell types from different species is developed.
Journal ArticleDOI
Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection.
Kyle Rosenke,Kimberly Meade-White,Michael Letko,Chad S Clancy,Frederick Hansen,Yanan Liu,Atsushi Okumura,Tsing Lee Tang-Huau,Rong Li,Greg Saturday,Friederike Feldmann,Dana P. Scott,Zhongde Wang,Vincent J. Munster,Michael A. Jarvis,Michael A. Jarvis,Heinz Feldmann +16 more
TL;DR: It is shown that intranasal inoculation of SARS-CoV-2 into Syrian hamsters consistently caused moderate broncho-interstitial pneumonia, with high viral lung loads and extensive virus shedding, but animals only displayed transient mild disease.
Posted ContentDOI
Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV
Michael Letko,Vincent J. Munster +1 more
TL;DR: An approach to rapidly screen lineage B betacoronaviruses, such as SARS-CoV and the recent 2019-nCoV, for receptor usage and their ability to infect cell types from different species is developed.
Journal ArticleDOI
Origin of the HIV-1 group O epidemic in western lowland gorillas
Mirela D’arc,Mirela D’arc,Ahidjo Ayouba,Amandine Esteban,Gerald H. Learn,Vanina Boué,Florian Liegeois,Lucie Etienne,Nikki Tagg,Fabian H. Leendertz,Christophe Boesch,Nadege Freda Madinda,Nadege Freda Madinda,Martha M. Robbins,Maryke Gray,Amandine Cournil,Marcel Ooms,Michael Letko,Viviana Simon,Viviana Simon,Paul M. Sharp,Beatrice H. Hahn,Eric Delaporte,Eitel Mpoudi Ngole,Martine Peeters +24 more
TL;DR: It is shown that HIV-1 group O, which spreads epidemically in west central Africa and is estimated to have infected around 100,000 people, originated by cross-species transmission from western lowland gorillas.
Journal ArticleDOI
Adaptive Evolution of MERS-CoV to Species Variation in DPP4.
Michael Letko,Kerri L. Miazgowicz,Kerri L. Miazgowicz,Rebekah McMinn,Rebekah McMinn,Stephanie N. Seifert,Isabel Sola,Luis Enjuanes,Aaron B. Carmody,Neeltje van Doremalen,Vincent J. Munster +10 more
TL;DR: It is demonstrated that MERS-CoV spike can utilize multiple paths to rapidly adapt to novel species variation in DPP4, and enhanced viral entry with suboptimal D PP4 by altering the surface charge of spike.