M
Michael Xie
Researcher at Princess Margaret Cancer Centre
Publications - 3
Citations - 468
Michael Xie is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: DNA damage & Endoplasmic reticulum. The author has an hindex of 1, co-authored 3 publications receiving 354 citations. Previous affiliations of Michael Xie include Ontario Institute for Cancer Research & University of Toronto.
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Journal ArticleDOI
Genomic hallmarks of localized, non-indolent prostate cancer
Michael Fraser,Veronica Y. Sabelnykova,Takafumi N. Yamaguchi,Lawrence E. Heisler,Julie Livingstone,Vincent Huang,Yu Jia Shiah,Fouad Yousif,Xihui Lin,Andre P. Masella,Natalie S. Fox,Natalie S. Fox,Michael Xie,Stephenie D. Prokopec,Alejandro Berlin,Emilie Lalonde,Emilie Lalonde,Musaddeque Ahmed,Dominique Trudel,Xuemei Luo,Timothy Beck,Alice Meng,Junyan Zhang,Alister D'Costa,Robert E. Denroche,Haiying Kong,Shadrielle Melijah G. Espiritu,Melvin L.K. Chua,Ada Wong,Taryne Chong,Michelle Sam,Jeremy Johns,Lee Timms,Nicholas Buchner,Michèle Orain,Valérie Picard,Hélène Hovington,Alexander Murison,Ken Kron,Nicholas J. Harding,Christine P'ng,Kathleen E. Houlahan,Kenneth C. Chu,Bryan Lo,Francis Nguyen,Constance H. Li,Constance H. Li,Ren X. Sun,Ren X. Sun,Richard de Borja,Christopher I Cooper,Julia F. Hopkins,Shaylan K. Govind,Clement Fung,Daryl Waggott,Jeffrey Green,Syed Haider,Michelle Chan-Seng-Yue,Esther Jung,Zhiyuan Wang,Alain Bergeron,Alan Dal Pra,Louis Lacombe,Colin Collins,Colin Collins,Cenk Sahinalp,Mathieu Lupien,Mathieu Lupien,Neil E. Fleshner,Housheng Hansen He,Housheng Hansen He,Yves Fradet,Bernard Têtu,Theodorus van der Kwast,John Douglas Mcpherson,John Douglas Mcpherson,Robert G. Bristow,Robert G. Bristow,Paul C. Boutros,Paul C. Boutros +79 more
TL;DR: It is suggested that intensified treatment of genomically aggressive localized prostate cancer may improve cure rates and numerous molecular aberrations were prognostic for disease recurrence, including several DNA methylation events, and a signature comprised of these aberration outperformed well-described prognostic biomarkers.
Journal ArticleDOI
NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4.
Pallavi Jain,Anna Dvorkin-Gheva,Anna Dvorkin-Gheva,Erik Mollen,Erik Mollen,Lucie Malbeteau,Michael Xie,Michael Xie,Fatima Jessa,Piriththiv Dhavarasa,Stephen Chung,Kevin R. Brown,Gun Ho Jang,Parth Vora,Parth Vora,Faiyaz Notta,Faiyaz Notta,Faiyaz Notta,Jason Moffat,David W. Hedley,David W. Hedley,Paul C. Boutros,Paul C. Boutros,Bradly G. Wouters,Bradly G. Wouters,Marianne Koritzinsky +25 more
TL;DR: In this article, the authors show that high NADPH levels drive activity of NADPH oxidase 4 (NOX4) expressed in the endoplasmic reticulum (ER) membrane.
Posted ContentDOI
NOX4 links metabolic regulation in pancreatic cancer to endoplasmic reticulum redox vulnerability and dependence on PRDX4
Pallavi Jain,Anna Dvorkin-Gheva,Erik Mollen,Erik Mollen,Michael Xie,Fatima Jessa,Piriththiv Dhavarasa,Stephen Chung,Kevin R. Brown,Gun Ho Jang,Faiyaz Notta,Faiyaz Notta,Faiyaz Notta,Jason Moffat,David W. Hedley,David W. Hedley,Paul C. Boutros,Paul C. Boutros,Bradly G. Wouters,Bradly G. Wouters,Marianne Koritzinsky +20 more
TL;DR: This study has identified NOX4 as a link between metabolic deregulation and ER-specific redox vulnerability in PDAC and suggests that PRDX4 represents a novel therapeutic target for pancreatic cancer that may be particularly potent in combination with radiotherapy.