Bryan Lo

TL;DR: It is suggested that intensified treatment of genomically aggressive localized prostate cancer may improve cure rates and numerous molecular aberrations were prognostic for disease recurrence, including several DNA methylation events, and a signature comprised of these aberration outperformed well-described prognostic biomarkers.

TL;DR: This work systematically elucidated key algorithmic problems in subclonal reconstruction, and developed mathematically valid quantitative metrics for evaluating them, then developed approaches to simulate realistic tumour genomes that harbour all known mutation types and processes.

TL;DR: In this paper , the extent of neuroendocrine differentiation in B-SqCC and the underlying molecular process was investigated. But, the authors were unable to identify the DEGs that are associated with pulmonary NE differentiation.

TL;DR: This paper provides the first detailed proposal for capturing an advanced diagnostics workload to enable appropriate pathologist allotment for performing all the steps required to run an advanced diagnostic service.

TL;DR: The Canadian NTRK (CANTRK) study is an interlaboratory comparison ring study to optimize testing for neurotrophic receptor tyrosine kinase (NTRK)-fusion in Canadian laboratories as mentioned in this paper .