T
Tobias Brambrink
Researcher at Massachusetts Institute of Technology
Publications - 10
Citations - 8504
Tobias Brambrink is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Embryonic stem cell & Induced pluripotent stem cell. The author has an hindex of 9, co-authored 10 publications receiving 8269 citations. Previous affiliations of Tobias Brambrink include University of Alabama at Birmingham.
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Journal ArticleDOI
In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
Marius Wernig,Alexander Meissner,Ruth K. Foreman,Tobias Brambrink,Manching Ku,Konrad Hochedlinger,Konrad Hochedlinger,Bradley E. Bernstein,Bradley E. Bernstein,Rudolf Jaenisch +9 more
TL;DR: The results show that the biological potency and epigenetic state of in-vitro-reprogrammed induced pluripotent stem cells are indistinguishable from those of ES cells.
Journal ArticleDOI
Polycomb complexes repress developmental regulators in murine embryonic stem cells
Laurie A. Boyer,Kathrin Plath,Kathrin Plath,Julia Zeitlinger,Tobias Brambrink,Lea Ann Medeiros,Tong Ihn Lee,Stuart S. Levine,Marius Wernig,Adriana Tajonar,Mridula K. Ray,George W. Bell,Arie P. Otte,Miguel Vidal,David K. Gifford,Richard A. Young,Rudolf Jaenisch +16 more
TL;DR: It is shown that PcG proteins directly repress a large cohort of developmental regulators in murine ES cells, the expression of which would otherwise promote differentiation, and dynamic repression of developmental pathways by Polycomb complexes may be required for maintaining ES cell pluripotency and plasticity during embryonic development.
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Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin
Jacob H. Hanna,Marius Wernig,Marius Wernig,Styliani Markoulaki,Styliani Markoulaki,Chiao-Wang Sun,Chiao-Wang Sun,Alexander Meissner,Alexander Meissner,John P. Cassady,John P. Cassady,Caroline Beard,Caroline Beard,Tobias Brambrink,Tobias Brambrink,Li-Chen Wu,Li-Chen Wu,Tim M. Townes,Tim M. Townes,Rudolf Jaenisch,Rudolf Jaenisch +20 more
TL;DR: It is shown that mice can be rescued after transplantation with hematopoietic progenitors obtained in vitro from autologous iPS cells, providing proof of principle for using transcription factor–induced reprogramming combined with gene and cell therapy for disease treatment in mice.
Journal ArticleDOI
Sequential Expression of Pluripotency Markers during Direct Reprogramming of Mouse Somatic Cells
Tobias Brambrink,Ruth K. Foreman,G. Grant Welstead,Christopher J. Lengner,Marius Wernig,Heikyung Suh,Rudolf Jaenisch +6 more
TL;DR: Using inducible constructs derived induced pluripotent stem (iPS) cells from mouse embryonic fibroblasts (MEFs) and found that transgene silencing is a prerequisite for normal cell differentiation, a step toward understanding some of the molecular events governing epigenetic reprogramming.
Journal ArticleDOI
Global loss of imprinting leads to widespread tumorigenesis in adult mice
Teresa M. Holm,Laurie Jackson-Grusby,Tobias Brambrink,Yasuhiro Yamada,William M. Rideout,Rudolf Jaenisch +5 more
TL;DR: It is demonstrated that LOI alone can predispose cells to tumorigenesis and a pathway through which immortality conferred by LOI lowers the threshold for transformation is identified.