S
Susan B. Powell
Researcher at University of California, San Diego
Publications - 86
Citations - 4818
Susan B. Powell is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Prepulse inhibition & Agonist. The author has an hindex of 35, co-authored 85 publications receiving 4345 citations. Previous affiliations of Susan B. Powell include Veterans Health Administration & University of California, Santa Cruz.
Papers
More filters
Journal ArticleDOI
Autism as a disorder of neural information processing: directions for research and targets for therapy
Matthew K. Belmonte,Edwin H. Cook,George M. Anderson,John L.R. Rubenstein,William T. Greenough,Andrea Beckel-Mitchener,Eric Courchesne,Lisa M. Boulanger,Susan B. Powell,Pat Levitt,E K Perry,Yong-hui Jiang,T M DeLorey,Elaine Tierney +13 more
TL;DR: Animal models based on genetic, neurochemical, neurophysiological, and behavioural manipulations offer the possibility of exploring developmental processes in detail, as do human studies addressing endophenotypes beyond the diagnosis itself.
Journal ArticleDOI
Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia.
TL;DR: There is a need for a "preclinical MATRICS" to develop a rodent test battery that is appropriate for drug development and outline an approach for translational research.
Journal ArticleDOI
Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model
Jane C. Naviaux,Lin Wang,Kefeng Li,A. Taylor Bright,William A. Alaynick,Kenneth R Williams,Kenneth R Williams,Susan B. Powell,Susan B. Powell,Robert K. Naviaux +9 more
TL;DR: The data show that antipurinergic therapy improves the multisystem, ASD-like features of both the environmental MIA, and the genetic Fragile X models.
Journal Article
5-Hydroxytryptamine2A Receptor Inverse Agonists as Antipsychotics
D. M. Weiner,Ethan S. Burstein,Norman Nash,G. E. Croston,E. A. Currier,Kimberly E. Vanover,Scott C. Harvey,E. M. Donohue,H. C. Hansen,Carl-Magnus A. Andersson,Tracy A. Spalding,D. F. C. Gibson,Kirsten Krebs-Thomson,Susan B. Powell,Mark A. Geyer,Uli Hacksell,Mark R. Brann +16 more
TL;DR: Functional high-throughput screening of a diverse chemical library identified 530 ligands with inverse agonist activity at 5-HT2A receptors, including several series of compounds related to known antipsychotics, as well as a number of novel chemistries.
Journal ArticleDOI
Prepulse inhibition and genetic mouse models of schizophrenia.
TL;DR: The usefulness of PPI in phenotype-driven approaches in which a PPI phenotype could lead to "bottom up" approaches of identifying novel genes of relevance to PPI (i.e., hypothesis generating) is discussed.