Mila Vlaskovska

TL;DR: Data from the present study strongly suggest a major sensory role for urothelially released ATP acting via P2X3 receptors on a subpopulation of pelvic afferent fibers.

TL;DR: Future research is needed to better understand whether diabetes control and prevention can modulate OA occurrence and progression and whether the presence of T2DM impacts on OA outcomes.

TL;DR: An expert working group was convened by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases to review the potential contribution of GMB to OA, and it is found that GMB is a critical determinant of drug metabolism and bioavailability and may influence the response of OA medications.

TL;DR: Prodynorphin (PDYN), precursor to dynorphin opioid peptides, is predominantly located in axon terminals and dendrites in hippocampal and striatal neurons, suggesting regional differences in the regulation of trafficking and processing of the precursor protein.

TL;DR: The conclusions of this review are that all alternative interventions definitely require clinical trials with robust methodology, to assess their efficacy and safety in the treatment of OA beyond contextual and placebo effects.