Kyle Concannon

TL;DR: A role for EMT in the blood-borne dissemination of human breast cancer is supported as both single cells and multicellular clusters, expressing known EMT regulators, including transforming growth factor (TGF)–β pathway components and the FOXC1 transcription factor.

TL;DR: Observations point to a physiological feedback mechanism that attenuates oncogene addiction-mediated cell death associated with the withdrawal of growth factor signaling and may therefore contribute to the development of resistance.

TL;DR: In this paper , the molecular consequences of targeted DNA-damage response inhibition, from tumor cell death to increased engagement of the anti-tumor immune response, are discussed and mechanistic and clinical rationale for pairing targeted DDRis with immunotherapy for enhanced tumor control.

TL;DR: Analysis of treatment responses in 10 patients suggested an association of mesenchymal CTCs with disease progression, and RNA sequencing of CTC clusters identified EMT-related signatures, including FOXC1, a known transcriptional regulator of EMT.

TL;DR: In this article , Gay CM et al. identified four major distinct subgroups of small cell lung cancer (SCLC): ASCL1, NEUROD, POU2F3 and inflamed phenotype.