M
Mindy S. Lo
Researcher at Boston Children's Hospital
Publications - 54
Citations - 2610
Mindy S. Lo is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Medicine & Systemic lupus erythematosus. The author has an hindex of 21, co-authored 46 publications receiving 1820 citations. Previous affiliations of Mindy S. Lo include Harvard University & Washington University in St. Louis.
Papers
More filters
Journal ArticleDOI
New insights into the immunopathogenesis of systemic lupus erythematosus
TL;DR: Improved understanding of the pathogenesis of SLE is driving a renewed interest in targeted therapy, and researchers are now on the verge of developing targeted immunotherapy directed at treating either specific organ system involvement or specific subsets of patients with SLE.
Journal ArticleDOI
Distinct clinical and immunological features of SARS-CoV-2-induced multisystem inflammatory syndrome in children.
Pui Y. Lee,Megan Day-Lewis,Lauren A. Henderson,Kevin G. Friedman,Jeffrey Lo,Jordan E Roberts,Mindy S. Lo,Craig D. Platt,Janet Chou,Kacie J Hoyt,Annette L. Baker,Tina Banzon,Margaret H. Chang,Ezra M. Cohen,Sarah D. de Ferranti,Audrey Dionne,Saddiq Habiballah,Olha Halyabar,Jonathan S. Hausmann,Melissa M. Hazen,Erin Janssen,Esra Meidan,Ryan W. Nelson,Alan A. Nguyen,Robert P. Sundel,Fatma Dedeoglu,Peter A. Nigrovic,Jane W. Newburger,Mary Beth F. Son +28 more
TL;DR: MIS-C encompasses a broad phenotypic spectrum with clinical and laboratory features distinct from Kawasaki disease and macrophage activation syndrome and improvement was observed in all cases, including 6 cases that did not require immunomodulatory therapy.
Journal ArticleDOI
Respiratory Syncytial Virus Nonstructural Proteins NS1 and NS2 Mediate Inhibition of Stat2 Expression and Alpha/Beta Interferon Responsiveness
TL;DR: It is shown that RSV preferentially inhibits IFN-α/β signaling by expression of viral NS1 and NS2 in epithelial host cells, which may contribute to viral host range, as well as immune subversion.
Journal ArticleDOI
Immunity, inflammation, and remodeling in the airway epithelial barrier: epithelial-viral-allergic paradigm.
Michael J. Holtzman,Jeffrey D. Morton,Laurie P. Shornick,Jeffrey W. Tyner,Mary P. O'Sullivan,Aurita Antao,Mindy S. Lo,Mario Castro,Michael J. Walter +8 more
TL;DR: Alternative evidence is summarized that the innate immune system, typified by actions of airway epithelial cells and macrophages, may also be specially programmed for antiviral defense and abnormally programmed in inflammatory disease.
Journal ArticleDOI
cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus.
Christian M. Hedrich,José C. Crispín,Thomas Rauen,Christina Ioannidis,Sokratis A. Apostolidis,Mindy S. Lo,Vasileios C. Kyttaris,George C. Tsokos +7 more
TL;DR: It is concluded that CREMα mediates epigenetic remodeling of the IL2 and IL17A gene during T-cell differentiation in favor of effector memory T cells in health and disease.