Journal ArticleDOI
New insights into the immunopathogenesis of systemic lupus erythematosus
TLDR
Improved understanding of the pathogenesis of SLE is driving a renewed interest in targeted therapy, and researchers are now on the verge of developing targeted immunotherapy directed at treating either specific organ system involvement or specific subsets of patients with SLE.Abstract:
In this Review, Tsokos et al. describe recent advances in our understanding of systemic lupus erythematosus (SLE) that are driving repurposing of existing drugs as well as development of new treatments. Cytokines, tolerance pathways, local tissue mediators, and epigenetic mechanisms all show promise as novel targeted therapies that could lead to individualized care in SLE.read more
Citations
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Mutations inFasAssociated withHuman Lymphoproliferative Syndrome and Autoimmunity
P. Lane,M. Lohoff,F. Rieux-Laucat,F. LeDeist,C. Hivroz,A. G. Roberts,K. M. Debatin,A. Fischer +7 more
TL;DR: Fas expression and function were analyzed in three children with a lymphoproliferative syndrome and may provide a molecular basis for some autoimmune diseases in humans.
Journal ArticleDOI
Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity.
Chu-Xiao Liu,Xiang Li,Fang Nan,Shan Jiang,Xiang Gao,Si-Kun Guo,Wei Xue,Yange Cui,Kaige Dong,Huihua Ding,Bo Qu,Zhaocai Zhou,Nan Shen,Nan Shen,Nan Shen,Li Yang,Li Yang,Ling-Ling Chen,Ling-Ling Chen +18 more
TL;DR: It is shown that endogenous circRNAs tend to form 16-26 bp imperfect RNA duplexes and act as inhibitors of double-stranded RNA (dsRNA)-activated protein kinase (PKR) related to innate immunity.
Journal ArticleDOI
Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 2 trial
Daniel J. Wallace,Richard Furie,Yoshiya Tanaka,Kenneth C. Kalunian,Marta Mosca,Michelle Petri,Thomas Dörner,Mario H. Cardiel,Ian N. Bruce,Elisa Gomez,Tara Carmack,Amy M. DeLozier,Jonathan Janes,Matthew D. Linnik,Stephanie de Bono,Maria E Silk,Robert W Hoffman +16 more
TL;DR: The baricitinib 4 mg dose, but not the 2mg dose, significantly improved the signs and symptoms of active systemic lupus erythematosus in patients who were not adequately controlled despite standard of care therapy, with a safety profile consistent with previous studies of baricit inib.
Journal ArticleDOI
Systemic lupus erythematosus: Diagnosis and clinical management.
Andrea Fava,Michelle Petri +1 more
TL;DR: The diagnostic approach as well as the etiopathogenetic rationale and clinical evidence for the management of SLE are reviewed, which includes lifestyle changes such as avoidance of ultraviolet light; prevention of comorbidities including coronary artery disease, osteoporosis, infections, and drug toxicities; use of immunomodulators and targeted therapy.
Journal ArticleDOI
Pathogenesis of Human Systemic Lupus Erythematosus: A Cellular Perspective
Vaishali R. Moulton,Abel Suárez-Fueyo,Esra Meidan,Esra Meidan,Hao Li,Masayuki Mizui,George C. Tsokos +6 more
TL;DR: Novel observations have provided an improved understanding of the contribution of tissue-specific factors and associated damage, T and B lymphocytes, as well as innate immune cell subsets and their corresponding abnormalities.
References
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Journal ArticleDOI
Systematic Review: Process of Forming Academic Service Partnerships to Reform Clinical Education
TL;DR: This study’s findings can provide practical guidelines to steer partnership programs within the academic and clinical bodies, with the aim of providing a collaborative partnership approach to clinical education.
Journal ArticleDOI
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Yukihiro Furusawa,Yuuki Obata,Shinji Fukuda,Takaho A. Endo,Gaku Nakato,Daisuke Takahashi,Yumiko Nakanishi,Chikako Uetake,Keiko Kato,Tamotsu Kato,Masumi Takahashi,Noriko N. Fukuda,Shinnosuke Murakami,Eiji Miyauchi,Shingo Hino,Koji Atarashi,Satoshi Onawa,Yumiko Fujimura,Trevor Lockett,Julie M. Clarke,David L. Topping,Masaru Tomita,Shohei Hori,Osamu Ohara,Tatsuya Morita,Haruhiko Koseki,Jun Kikuchi,Kenya Honda,Koji Hase,Hiroshi Ohno +29 more
TL;DR: It is shown that a large bowel microbial fermentation product, butyrate, induces the differentiation of colonic Treg cells in mice and ameliorated the development of colitis induced by adoptive transfer of CD4+ CD45RBhi T cells in Rag1−/− mice.
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Role of the Microbiota in Immunity and Inflammation
Yasmine Belkaid,Timothy W. Hand +1 more
TL;DR: In high-income countries, overuse of antibiotics, changes in diet, and elimination of constitutive partners, such as nematodes, may have selected for a microbiota that lack the resilience and diversity required to establish balanced immune responses.
Journal ArticleDOI
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Nicholas Arpaia,Clarissa Campbell,Xiying Fan,Stanislav Dikiy,Joris van der Veeken,Paul deRoos,Hui Liu,Justin R. Cross,Klaus Pfeffer,Paul J. Coffer,Alexander Y. Rudensky +10 more
TL;DR: The results suggest that bacterial metabolites mediate communication between the commensal microbiota and the immune system, affecting the balance between pro- and anti-inflammatory mechanisms.
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