M
Ming Chen
Researcher at University of Tennessee
Publications - 29
Citations - 2413
Ming Chen is an academic researcher from University of Tennessee. The author has contributed to research in topics: Mitochondrial fission & Mitochondrion. The author has an hindex of 14, co-authored 26 publications receiving 1856 citations. Previous affiliations of Ming Chen include Baylor University & Chinese Academy of Sciences.
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Journal ArticleDOI
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
Lei Liu,Du Feng,Guo Chen,Ming Chen,Qiaoxia Zheng,Pingping Song,Qi Ma,Chongzhuo Zhu,Rui Wang,Wanjun Qi,Lei Huang,Peng Xue,Baowei Li,Xiaohui Wang,Haijing Jin,Jun Wang,Fuquan Yang,Pingsheng Liu,Yushan Zhu,Sen-Fang Sui,Quan Chen,Quan Chen +21 more
TL;DR: It is reported that FUNDC1, an integral mitochondrial outer-membrane protein, is a receptor for hypoxia-induced mitophagy, and its findings offer insights into mitochondrial quality control in mammalian cells.
Journal ArticleDOI
Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy.
Ming Chen,Ziheng Chen,Yueying Wang,Zheng Tan,Chongzhuo Zhu,Yanjun Li,Zhe Han,Linbo Chen,Ruize Gao,Lei Liu,Quan Chen +10 more
TL;DR: The data suggest that FUNDC1 regulates both mitochondrial fission or fusion and mitophagy and mediates the “coupling” across the double membrane for mitochondrial dynamics and quality control.
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NLLSS: Predicting Synergistic Drug Combinations Based on Semi-supervised Learning.
TL;DR: This study proposed similar nature of drug combinations: principal drugs which obtain synergistic effect with similar adjuvant drugs are often similar and vice versa and developed a novel algorithm termed Network-based Laplacian regularized Least Square Synergistic drug combination prediction (NLLSS) to predict potential synergistic drug combinations by integrating different kinds of information.
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Increasing occurrence of antimicrobial resistant hypervirulent (hypermucoviscous) Klebsiella pneumoniae isolates in China
TL;DR: Resistance to all the tested antimicrobials, except carbapenems and amikacin, was observed in a proportion of hvKP strains, 17% (5/29) of which expressed extended-spectrum β-lactamase, indicating an increasing propensity for the acquisition of antimicrobial resistance.
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A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30
Wen Yue,Ziheng Chen,Hai-Yang Liu,Chen Yan,Ming Chen,Du Feng,Chaojun Yan,Hao Wu,Lei Du,Yueying Wang,Jinhua Liu,Xiaohu Huang,Laixin Xia,Lei Liu,Xiaohui Wang,Haijing Jin,Jun Wang,Zhiyin Song,Xiao-Jiang Hao,Quan Chen,Quan Chen +20 more
TL;DR: A diterpenoid derivative 15-oxospiramilactone (S3) is identified that potently induced mitochondrial fusion to restore the mitochondrial network and oxidative respiration in cells that are deficient in either Mfn1 or Mfn2.