M
Ming Zhou
Researcher at University of Texas Southwestern Medical Center
Publications - 4
Citations - 1349
Ming Zhou is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Arthritis & HLA-B27. The author has an hindex of 4, co-authored 4 publications receiving 1284 citations. Previous affiliations of Ming Zhou include Brooklyn Hospital Center & University of Texas at Dallas.
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Journal ArticleDOI
The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats
Joel D. Taurog,James A. Richardson,JoAnne T. Croft,William A. Simmons,William A. Simmons,Ming Zhou,Ming Zhou,José Luis Fernández-Sueiro,Edward Balish,Robert E. Hammer +9 more
TL;DR: It is reported here that B27 transgenic rats raised in a germfree environment do not develop inflammatory intestinal or peripheral joint disease, whereas the skin and genital inflammatory lesions are unaffected by the germfree state, and these findings support the concept that gut and joint inflammation are pathogenetically closely related.
Journal ArticleDOI
Inflammatory disease in HLA-B27 transgenic rats
Joel D. Taugor,Shanna D. Maika,Nimman Satumtira,Martha L. Dorris,Ian Lochlan McLean,Hiromi Yanagisawa,Alain Sayad,Andrew J. Stagg,Graham M. Fox,Anne Le O'Brein,Muhammad I. Rehman,Ming Zhou,Allison L. Weiner,Judy B. Splawski,James A. Richardson,Robert E. Hammer +15 more
TL;DR: The spondyloarthropathy‐like disease in rats is specific for HLA‐B27 but does not require Cys67, and Arthritis but not colitis is particularly sensitive to B27 peptide‐binding specificity.
Journal ArticleDOI
The Specificity of Peptides Bound to Human Histocompatibility Leukocyte Antigen (HLA)-B27 Influences the Prevalence of Arthritis in HLA-B27 Transgenic Rats
Ming Zhou,Ming Zhou,Alain Sayad,William A. Simmons,Richard C. Jones,Shanna D. Maika,Shanna D. Maika,Nimman Satumtira,Martha L. Dorris,Simon J. Gaskell,Robert S. Bordoli,R. Balfour Sartor,Clive A. Slaughter,James A. Richardson,Robert E. Hammer,Joel D. Taurog +15 more
TL;DR: The hypothesis that B27-related arthritis requires binding of a specific peptide or set of peptide to B27 is supported, and a method for efficient transgenic targeting of peptides to the ER is demonstrated.
Journal ArticleDOI
A new MHC locus that influences class I peptide presentation.
William A. Simmons,Derry C. Roopenian,Scott G. Summerfield,Richard C. Jones,Begona Galocha,Gregory J. Christianson,Shanna D. Maika,Ming Zhou,Simon J. Gaskell,Robert S. Bordoli,Hidde L. Ploegh,Clive A. Slaughter,Kirsten Fischer Lindahl,Robert E. Hammer,Joel D. Taurog +14 more
TL;DR: A homologous locus with similar polymorphism exists in the rat, and it was found to exert a broad effect on peptide loading of both HLA-B27 and mouse class I alleles, establishing a strong, previously unrecognized MHC-encoded influence on the class I antigen pathway.