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Derry C. Roopenian
Researcher at Tufts University
Publications - 211
Citations - 16371
Derry C. Roopenian is an academic researcher from Tufts University. The author has contributed to research in topics: Antigen & Major histocompatibility complex. The author has an hindex of 60, co-authored 206 publications receiving 15087 citations. Previous affiliations of Derry C. Roopenian include Gulf Coast Regional Blood Center & Vanderbilt University.
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Journal ArticleDOI
FcRn: the neonatal Fc receptor comes of age
TL;DR: The neonatal Fc receptor for IgG (FcRn) has been well characterized in the transfer of passive humoral immunity from a mother to her fetus and throughout life, FcRm protects IgG from degradation, thereby explaining the long half-life of this class of antibody in the serum.
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Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6
Katsutoshi Ozaki,Katsutoshi Ozaki,Rosanne Spolski,Rachel Ettinger,Hyoung F. Kim,Gang Wang,Chen Feng Qi,Patrick Hwu,Daniel J. Shaffer,Shreeram Akilesh,Derry C. Roopenian,Herbert C. Morse,Peter E. Lipsky,Warren J. Leonard +13 more
TL;DR: It is demonstrated that although IL-21 induces death of resting B cells, it promotes differentiation of B cells into postswitch and plasma cells, explaining howIL-21 can be proapoptotic for B cells in vitro yet critical for Ag-specific Ig production in vivo.
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Enhanced antibody half-life improves in vivo activity
Jonathan Zalevsky,Aaron Chamberlain,Holly M. Horton,Sher Bahadur Karki,Irene W.L. Leung,Thomas J. Sproule,Greg A. Lazar,Derry C. Roopenian,John R. Desjarlais +8 more
TL;DR: It is observed that prolonged exposure due to FcRn-mediated enhancement of half-life improved antitumor activity of Fc-engineered antibodies in an hFc Rn/Rag1−/− mouse model, which bridges the demand for dosing convenience with the clinical necessity of maintaining efficacy.
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The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan.
Chaity Chaudhury,Samina Mehnaz,John M. Robinson,William L. Hayton,Dennis K. Pearl,Derry C. Roopenian,Clark L. Anderson +6 more
TL;DR: These results affirm the hypothesis that the major histocompatibility complex–related Fc receptor protects albumin from degradation just as it does IgG, prolonging the half-lives of both.
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Human Neonatal Fc Receptor Mediates Transport of IgG into Luminal Secretions for Delivery of Antigens to Mucosal Dendritic Cells
Masaru Yoshida,Steven M. Claypool,Jessica Wagner,Emiko Mizoguchi,Atsushi Mizoguchi,Derry C. Roopenian,Wayne I. Lencer,Wayne I. Lencer,Richard S. Blumberg,Richard S. Blumberg +9 more
TL;DR: It is found that the human neonatal Fc receptor (FcRn) is the vehicle that transports IgG across the intestinal epithelial barrier into the lumen where the IgG can bind cognate antigen.