M
Mireille Blanchard-Desce
Researcher at Centre national de la recherche scientifique
Publications - 145
Citations - 4205
Mireille Blanchard-Desce is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Two-photon absorption & Singlet oxygen. The author has an hindex of 36, co-authored 145 publications receiving 3688 citations. Previous affiliations of Mireille Blanchard-Desce include University of Rennes & University of Bordeaux.
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Journal ArticleDOI
New quadrupolar fluorophores with high two-photon excited fluorescence
TL;DR: In this article, new quadrupolar fluorophores that exhibit enhanced two-photon excited fluorescence were designed according to a molecular engineering approach based on push-push and pull-pull elongated molecules built from a rigid conjugated core (either dihydrophenanthrene or dithienothiophene).
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Nanoparticles restore lysosomal acidification defects: Implications for Parkinson and other lysosomal-related diseases.
Mathieu Bourdenx,Jonathan Daniel,Emilie Genin,Federico N. Soria,Mireille Blanchard-Desce,Erwan Bezard,Benjamin Dehay +6 more
TL;DR: It is demonstrated that poly(DL-lactide-co-glycolide) (PLGA) acidic nanoparticles (aNP) restore impaired lysosomal function in a series of toxin and genetic cellular models of PD, i.e. ATP13A2-mutant or depleted cells or glucocerebrosidase (GBA)-mutant cells, as well as in a genetic model of lysOSomal-related myopathy.
Journal ArticleDOI
Two‐Photon Excitation of Porphyrin‐Functionalized Porous Silicon Nanoparticles for Photodynamic Therapy
Emilie Secret,Marie Maynadier,Marie Maynadier,Audrey Gallud,Arnaud Chaix,Elise Bouffard,Magali Gary-Bobo,Nathalie Marcotte,Olivier Mongin,Olivier Mongin,Khaled El Cheikh,Vincent Hugues,Mélanie Auffan,Céline Frochot,Céline Frochot,Alain Morère,Philippe Maillard,Philippe Maillard,Mireille Blanchard-Desce,Mireille Blanchard-Desce,Michael J. Sailor,Marcel Garcia,Jean-Olivier Durand,Jean-Olivier Durand,Frédérique Cunin +24 more
TL;DR: Mannose-functionalized pSiNPs can be vectorized to MCF-7 human breast cancer cells through a mannose receptor-mediated endocytosis mechanism to provide a 3-fold enhancement of the 2-photon PDT effect.
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Two-photon-triggered drug delivery via fluorescent nanovalves.
Jonas G. Croissant,Arnaud Chaix,Arnaud Chaix,Olivier Mongin,Miao Wang,Sébastien Clément,Laurence Raehm,J.O. Durand,Vincent Hugues,Mireille Blanchard-Desce,Marie Maynadier,Audrey Gallud,Magali Gary-Bobo,Marcel Garcia,Jie Lu,Fuyuhiko Tamanoi,Daniel P. Ferris,Derrick Tarn,Jeffrey I. Zink +18 more
TL;DR: Mesoporous silica nanoparticles are functionalized in the walls with an original fluorophore with a high two-photon absorption cross-section and cancer cell killing is observed due to the two- photon-triggered opening of the pores through FRET and the release of the anticancer drug from the MSN.
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Nonlinear optical chromophores containing dithienothiophene as a new type of electron relay
TL;DR: In this paper, the NLO donor-acceptor (D-A) chromophores containing a fused terthiophene (DTT) as electron relay were synthesized to evaluate the relay's role in the solvatochromism as well as in the molecular nonlinearity, µβ(0).