M
Mirna Perez-Moreno
Researcher at University of Copenhagen
Publications - 33
Citations - 7915
Mirna Perez-Moreno is an academic researcher from University of Copenhagen. The author has contributed to research in topics: Cadherin & Catenin. The author has an hindex of 18, co-authored 32 publications receiving 7378 citations. Previous affiliations of Mirna Perez-Moreno include BBVA Compass & CINVESTAV.
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Journal ArticleDOI
The transcription factor Snail controls epithelial–mesenchymal transitions by repressing E-cadherin expression
Amparo Cano,Mirna Perez-Moreno,Isabel Rodrigo,Annamaria Locascio,Maria Blanco,Marta G. del Barrio,Francisco Portillo,M. Angela Nieto +7 more
TL;DR: It is shown that mouse Snail is a strong repressor of transcription of the E-cadherin gene, opening up new avenues for the design of specific anti-invasive drugs.
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The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors.
Victoria Bolós,Héctor Peinado,Mirna Perez-Moreno,Mirna Perez-Moreno,Mario F. Fraga,Manel Esteller,Amparo Cano +6 more
TL;DR: The idea that the in vivo action of the different factors in E-cadherin repression can be modulated by their relative concentrations as well as by specific cellular or tumour contexts is supported.
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Sticky Business: Orchestrating Cellular Signals at Adherens Junctions
TL;DR: Cohesive sheets of epithelial cells are a fundamental feature of multicellular organisms and are largely a product of the varied functions of adherens junctions, but understanding the underlying mechanisms that govern these conserved cellular rearrangements is a prerequisite to understanding vertebrate morphogenesis.
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Epithelial cell polarity, stem cells and cancer
TL;DR: Some advances are highlighted in the understanding of how loss of epithelial cell polarity contributes to tumorigenesis.
Journal ArticleDOI
A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions.
Mirna Perez-Moreno,Annamaria Locascio,Isabel Rodrigo,Goedele Dhondt,Francisco Portillo,Maria Angela Nieto,Amparo Cano +6 more
TL;DR: It is shown that the mouse E12/E47 basic helix-loop-helix transcription factor (the E2A gene product) acts as a repressor of E-cadherin expression and triggers epithelial-mesenchymal transitions.