M
Mitsuru Imamura
Researcher at Cornell University
Publications - 5
Citations - 258
Mitsuru Imamura is an academic researcher from Cornell University. The author has contributed to research in topics: Lung & Lung injury. The author has an hindex of 5, co-authored 5 publications receiving 125 citations. Previous affiliations of Mitsuru Imamura include NewYork–Presbyterian Hospital.
Papers
More filters
Journal ArticleDOI
Mitofusins Regulate Lipid Metabolism to Mediate the Development of Lung Fibrosis
Kuei-Pin Chung,Kuei-Pin Chung,Chia-Lang Hsu,Li Chao Fan,Ziling Huang,Divya Bhatia,Yi Jung Chen,Shu Hisata,Soo Jung Cho,Kiichi Nakahira,Mitsuru Imamura,Mary E. Choi,Mary E. Choi,Chong-Jen Yu,Chong-Jen Yu,Suzanne M. Cloonan,Augustine M.K. Choi,Augustine M.K. Choi +17 more
TL;DR: It is shown that loss of mitofusin1 and mit ofusin2 in murine AEC2 cells leads to the development of lung fibrosis through the regulation of surfactant lipids.
Journal ArticleDOI
RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase
Mitsuru Imamura,Jong Seok Moon,Jong Seok Moon,Kuei-Pin Chung,Kiichi Nakahira,Thangamani Muthukumar,Roman Shingarev,Stefan W. Ryter,Augustine M.K. Choi,Augustine M.K. Choi,Mary E. Choi +10 more
TL;DR: A pathway by which RIPK3 promotes kidney fibrosis independently of MLKL-dependent necroptosis as a promising therapeutic target in CKD is identified.
Journal ArticleDOI
RIPK3 mediates pathogenesis of experimental ventilator-induced lung injury
Ilias I. Siempos,Ilias I. Siempos,Kevin C. Ma,Mitsuru Imamura,Rebecca M. Baron,Laura E. Fredenburgh,Jin Won Huh,Jong Seok Moon,Eli J. Finkelsztein,Daniel S. Jones,Michael Torres Lizardi,Edward J. Schenck,Stefan W. Ryter,Kiichi Nakahira,Augustine M.K. Choi +14 more
TL;DR: It is shown that plasma levels of RIPK3, but not MLKL, were higher in patients with MV than in patients without MV in two large intensive care unit cohorts, suggesting that FAO-dependent RIPK 3 mediates pathogenesis of acute lung injury.
Journal ArticleDOI
Cigarette smoke-initiated autoimmunity facilitates sensitisation to elastin-induced COPD-like pathologies in mice.
Jie Sen Zhou,Zhou-Yang Li,Xu Chen Xu,Yun Zhao,Yong Wang,Hai Pin Chen,Min Zhang,Yin Fang Wu,Tianwen Lai,Chun Hong Di,Ling Ling Dong,Juan Liu,Nan Xia Xuan,Chen Zhu,Yanping Wu,Hua Qiong Huang,Fu Gui Yan,Wen Hua,Yi Wang,Wei Ning Xiong,Hui Qiu,Tao Chen,Dong Weng,Hui Ping Li,Xiaobo Zhou,Lie Wang,Fang Liu,Xin Lin,Songmin Ying,Wen Li,Mitsuru Imamura,Mary E. Choi,Martin R. Stämpfli,Augustine M.K. Choi,Zhihua Chen,Huahao Shen +35 more
TL;DR: It is demonstrated that MMP12-generated elastin fragments serve as a self-antigen and drive the cigarette smoke-induced autoimmune processes in mice that result in a bronchitis-like phenotype and airspace enlargement.
Journal ArticleDOI
Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity
Maria Plataki,Li Chao Fan,Elizabeth Sanchez,Ziling Huang,Lisa K. Torres,Mitsuru Imamura,Yizhang Zhu,David E. Cohen,Suzanne M. Cloonan,Augustine M.K. Choi +9 more
TL;DR: It is demonstrated that high fat diet induced obesity increases the severity of hyperoxic acute lung injury in mice in part by altering fatty acid synthase (FASN) levels in the lung and that both a high diet and reduced FASN expression in alveolar epithelial cells promote lung injury.