Kiichi Nakahira

TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: This study suggests that autophagic proteins regulate NALP3-dependent inflammation by preserving mitochondria integrity and cytosolic translocation of mitochondrial DNA in response to lipopolysaccharide and ATP in macrophages.

TL;DR: Cell death mechanisms have been studied across a broad spectrum of models of oxidative stress, including H2O2, nitric oxide and derivatives, endotoxin-induced inflammation, photodynamic therapy, ultraviolet-A and ionizing radiations, and cigarette smoke.

TL;DR: Given that the majority of the biological and human health variables remained stable, or returned to baseline, after a 340-day space mission, these data suggest that human health can be mostly sustained over this duration of spaceflight.

TL;DR: It is shown that TLR4 recruitment to lipid rafts and dimerization were coupled events mediated at least in part by NADPH oxidase-dependent reactive oxygen species generation, which provides a new insight in understanding the mechanism by which fatty acids differentially modulateTLR4-mediated signaling pathway and consequent inflammatory responses which are implicated in the development and progression of many chronic diseases.